Dalphene Index

Registered clinical trials by aesthetic technique

Updated Jul 26, 2026

All 25 modalities' ClinicalTrials.gov registrations, each with the live query that produced the count.

Registered studies, every modality

29 modalities · 1,717 registrationsmethod →

Each bar is one modalityModalityA family of treatments that work the same way — such as radiofrequency microneedling, or lasers that leave the skin surface intact — rather than any one branded machine. and counts registered studiesRegistered studyA study written into the public registry, which records that someone planned or ran it and says nothing about whether it finished or what it found. on ClinicalTrials.govClinicalTrials.govThe United States public registry where the people running a study record it before or during the study, which is where this site's study counts come from.. Under it is the category the modality sits in.

ClinicalTrials.gov registrations naming each modality

registered studies

Topical retinoid is the largest bar at 343 registered studies, 20% of the 1,717 shown, while the 2 smallest bars each show 4.

ClinicalTrials.gov registration counts for every tracked modality
Registered studies
Topical retinoid343
Ablative / hybrid fractional laser229
Botulinum toxin (cosmetic)186
Mechanical microneedling135
Non-ablative fractional laser128
Human acellular dermal matrix (ECM) booster106
Exosome / extracellular-vesicle preparation79
Pulsed dye laser72
Topical hydroquinone / triple combination51
PDLLA / PLLA collagen biostimulator49
Hyaluronic acid filler46
IPL / broadband light43
Radiofrequency microneedling37
Laser hair removal30
Bimatoprost for eyelash growth28
Picosecond laser (pigment & tattoo)27
Topical clascoterone21
Cryolipolysis20
Poly-L-lactic acid collagen stimulator17
Polynucleotide (PDRN) skin booster16
Ultrasound lifting & tightening16
Hydradermabrasion9
Monopolar RF skin tightening9
Calcium hydroxylapatite filler7
Sebaceous-gland laser for acne5
Cellulite septa release4
High-intensity electromagnetic muscle stimulation4
Non-invasive laser lipolysis0
RF body contouring0

Registered studies naming the treatment — registration is not completion, publication or a result.

Every modality, with its live query

114 recruiting across 29 modalitiesmethod →

ClinicalTrials.gov registrations per modality, the recruiting subset, the 10-year publication count and the exact query behind each number.

ModalityCategoryRegistered studiesRecruiting nowPapers, last 10 yearsPubMedThe United States National Library of Medicine's index of published medical literature, which is where this site's paper counts come from.Products in this indexLive query
Topical retinoidSkin & Topicals343141,3325 · Aklief, Differin, Renova, Retin-A, Tazoracall · recruiting
Ablative / hybrid fractional laserLasers & Light229139408 · AcuPulse, Alma Hybrid, CO2RE, Halo, SP Dynamis, SmartXide, UltraPulse, eCO2all · recruiting
Botulinum toxin (cosmetic)Injectables18641,3626 · Botox Cosmetic, Daxxify, Dysport, Jeuveau, Letybo, Xeominall · recruiting
Mechanical microneedlingRF & Microneedling135135645 · MicroPen EVO, Rejuvapen NXT, SkinPen, SkinStylus, ellacorall · recruiting
Non-ablative fractional laserLasers & Light128107424 · Clear + Brilliant, Frax, Fraxel, LaseMDall · recruiting
Human acellular dermal matrix (ECM) boosterInjectables106121123 · CellREDM, Elravie Re2O, Juveacellall · recruiting
Exosome / extracellular-vesicle preparationInjectables79182,3531 · ASCE+all · recruiting
Pulsed dye laserLasers & Light7236132 · Cynergy, Vbeamall · recruiting
Topical hydroquinone / triple combinationSkin & Topicals5145091 · Tri-Lumaall · recruiting
PDLLA / PLLA collagen biostimulatorInjectables4963361 · AestheFillall · recruiting
Hyaluronic acid fillerInjectables4631,03316 · Belotero Balance, Belotero Intense (+) Lidocaine, Belotero Volume (+) Lidocaine, Juvederm Ultra XC, Juvederm Volbella XC, Juvederm Vollure XC, Juvederm Voluma XC, Juvederm Volux XC, Profhilo, RHA Collection, Restylane Defyne, Restylane Kysse, Restylane Lyft, Restylane Silk, Revanesse Versa, SKINVIVE by Juvedermall · recruiting
IPL / broadband lightLasers & Light4354885 · BBL, Harmony XL, Icon, Nordlys, Stellar M22all · recruiting
Radiofrequency microneedlingRF & Microneedling37130416 · Agnes RF, EndyMed Intensif, Fractora, Genius, INTRAcel, Infini, Morpheus8, Potenza, Profound, Scarlet SRF, Secret Pro, Secret RF, Sylfirm X, Venus Viva, VirtueRF, Vivaceall · recruiting
Laser hair removalLasers & Light30135911 · Apogee Elite, Clarity II, Diolaze, Elite iQ, GentleLase, GentleMax Pro, LightSheer, Motus, Soprano, Splendor X, Vectusall · recruiting
Bimatoprost for eyelash growthSkin & Topicals280521 · Latisseall · recruiting
Picosecond laser (pigment & tattoo)Lasers & Light2703066 · Discovery Pico, PicoCare, PicoPlus, PicoSure, PicoWay, enlightenall · recruiting
Topical clascoteroneSkin & Topicals212881 · Winleviall · recruiting
CryolipolysisBody Contouring2001992 · CoolSculpting, CoolSculpting Eliteall · recruiting
Poly-L-lactic acid collagen stimulatorInjectables1703711 · Sculptraall · recruiting
Polynucleotide (PDRN) skin boosterInjectables1621211 · Rejuranall · recruiting
Ultrasound lifting & tighteningBody Contouring1612612 · Sofwave, Ultherapyall · recruiting
HydradermabrasionSkin & Topicals90731 · HydraFacialall · recruiting
Monopolar RF skin tighteningRF & Microneedling912933 · TempSure, Thermage, Volnewmerall · recruiting
Calcium hydroxylapatite fillerInjectables704081 · Radiesseall · recruiting
Sebaceous-gland laser for acneLasers & Light51402 · Accure, AviClearall · recruiting
Cellulite septa releaseBody Contouring40453 · Aveli, Cellfina, Cellulazeall · recruiting
High-intensity electromagnetic muscle stimulationBody Contouring40612 · CoolTone, Emsculpt NEOall · recruiting
Non-invasive laser lipolysisBody Contouring00494 · Emerald Laser, SculpSure, Venus Bliss, Zeronaall · recruiting
RF body contouringBody Contouring001747 · Accent, Exilis, NuEra Tight, VelaShape, Venus Legacy, truSculpt, truSculpt iDall · recruiting

“Recruiting now” is a snapshot taken on the fetch date, not a trend — open the query to see today's number.