Dalphene Index

Who funded the trials, and how much of it came back

Updated Jul 26, 2026

Who funded the registered trials, how many humans were actually enrolled, how much of it came back — and what each modality's publication total is made of.

1,467Registered studies read25 modalities · 0 failed requests
38%Industry-led562 of 1,467 studies with a known sponsor class
35%Completed studies with results posted318 of 913 completed
350PubMed count queries run0 failed · pt-v1-2026-07-26

Facts about the two fetches behind this page — who registered the studies and how much came back, never how well anything works.

Who funded the trials

23 modalities · 1,467 studies with a known sponsor classmethod →

Each column is one modalityModalityA family of treatments that work the same way — such as radiofrequency microneedling, or lasers that leave the skin surface intact — rather than any one branded machine.; each band is the lead-sponsor classSponsor classThe registry's grouping of who ran a study — a company, the national health agency, another government body, or the catch-all bucket that holds hospitals and universities. that ClinicalTrials.govClinicalTrials.govThe United States public registry where the people running a study record it before or during the study, which is where this site's study counts come from. recorded on the study. Colours here are sponsor classes, not site categories.

Axis labels are shortened names. Terms in them: Dermal fillerDermal fillerAn injected gel that adds volume under the skin. · NeuromodulatorNeuromodulatorAn injected product that temporarily relaxes a muscle, which is the category botulinum toxin products sit in. · RFRFRadiofrequency: energy that heats tissue from the inside by passing an electrical current through it rather than by shining light on it. · BBLBBLBroadband light: one manufacturer's name for its intense pulsed light platform.

Lead-sponsor class of every registered study, by modality

share of each modality's registered studies

University, hospital or other accounts for 86–92% of registered trials for Pulsed dye laser, Ablative / hybrid fractional laser and Non-ablative fractional laser, and 14–23% for Topical clascoterone, Hyaluronic acid filler and Botulinum toxin (cosmetic); 6 modalities with fewer than 10 registered trials are not compared.

0255075100100Muscle stim.ClascoteroneHyaluronicBotulinumBimatoprostCalciumMonopolar RFRF needlingPicosecondRetinoidPoly-L-lacticAcne laserUltrasoundBroadbandHydroquinoneCryolipolysisHair removalCelluliteMicroneedlingNon-ablativeHydradermAblative100Pulsed dye
Other524%

Other combines 5 series each under 3% of the total: NIH, Other US federal agency, Other government, Research network and Individual. Each keeps its own colour in the chart and its own row in the data table.

Lead-sponsor class mix per modality, in whole percentage points of that modality's registered studies (they sum to 100 by largest remainder; the study counts are in the table below)
IndustryNIHOther US federal agencyOther governmentResearch networkIndividualUniversity, hospital or otherTotal
Muscle stim.100000000100
Clascoterone860000014100
Hyaluronic810004015100
Botulinum750011023100
Bimatoprost710000425100
Calcium710000029100
Monopolar RF560000044100
RF needling540000046100
Picosecond480040048100
Retinoid471021148100
Poly-L-lactic470060047100
Acne laser400000060100
Ultrasound380060056100
Broadband370032058100
Hydroquinone350042059100
Cryolipolysis350000065100
Hair removal340030063100
Cellulite250000075100
Microneedling180160075100
Non-ablative120011086100
Hydraderm1100011078100
Ablative110021086100
Pulsed dye80000092100

Colours here are lead-sponsor classes, not site categories. Lead sponsor only: a trial run by a university on a manufacturer's grant is classed by its registered lead sponsor.

Industry funding is not evidence of bad science — this measures who registered and paid for the trials, nothing else.

Lead-sponsor class of every fetched study, as counts rather than percentages, for each modality drawn in the figure above.
ModalityRegistered studiesIndustryNIHOther US federal agencyOther governmentResearch networkIndividualUniversity, hospital or other
High-intensity electromagnetic muscle stimulation44000000
Topical clascoterone2118000003
Hyaluronic acid filler4637000207
Botulinum toxin (cosmetic)1861390022043
Bimatoprost for eyelash growth2820000017
Calcium hydroxylapatite filler75000002
Monopolar RF skin tightening95000004
Radiofrequency microneedling37200000017
Picosecond laser (pigment & tattoo)27130010013
Topical retinoid34316321822165
Poly-L-lactic acid collagen stimulator178001008
Sebaceous-gland laser for acne52000003
Ultrasound lifting & tightening166001009
IPL / broadband light43160011025
Topical hydroquinone / triple combination51180021030
Cryolipolysis2070000013
Laser hair removal30100010019
Cellulite septa release41000003
Mechanical microneedling1352401900101
Non-ablative fractional laser1281500110111
Hydradermabrasion91000107
Ablative / hybrid fractional laser2292401520197
Pulsed dye laser7260000066

Lead-sponsor class of every registered study, per modality. Industry share is computed over studies with a KNOWN sponsor class; no study on this run was missing one.

ModalityCategoryRegistered studiesRegistered studyA study written into the public registry, which records that someone planned or ran it and says nothing about whether it finished or what it found.Industry shareIndustry sponsorA study whose responsible organisation is a company rather than a hospital, university or government body.IndustryNIHOther US federal agencyOther governmentResearch networkIndividualUniversity, hospital or otherNon-industry
High-intensity electromagnetic muscle stimulationBody Contouring4100%40000000
Topical clascoteroneSkin & Topicals2186%180000033
Hyaluronic acid fillerInjectables4680%370002079
Botulinum toxin (cosmetic)Injectables18675%139002204347
Bimatoprost for eyelash growthSkin & Topicals2871%200000178
Calcium hydroxylapatite fillerInjectables771%50000022
Monopolar RF skin tighteningRF & Microneedling956%50000044
Radiofrequency microneedlingRF & Microneedling3754%20000001717
Picosecond laser (pigment & tattoo)Lasers & Light2748%13001001314
Topical retinoidSkin & Topicals34348%16321822165180
Poly-L-lactic acid collagen stimulatorInjectables1747%80010089
Sebaceous-gland laser for acneLasers & Light540%20000033
Ultrasound lifting & tighteningBody Contouring1638%600100910
IPL / broadband lightLasers & Light4337%16001102527
Topical hydroquinone / triple combinationSkin & Topicals5135%18002103033
CryolipolysisBody Contouring2035%7000001313
Laser hair removalLasers & Light3033%10001001920
Cellulite septa releaseBody Contouring425%10000033
Mechanical microneedlingRF & Microneedling13518%2401900101111
Non-ablative fractional laserLasers & Light12812%1500110111113
HydradermabrasionSkin & Topicals911%10001078
Ablative / hybrid fractional laserLasers & Light22910%2401520197205
Pulsed dye laserLasers & Light728%6000006666

“University, hospital or other” is the registry's catch-all class, not a third kind of funder.

Humans actually tested

23 modalities · actual enrolment onlymethod →

One row per modality. The bar is the middle half of that modality's actual enrolment counts — the 25th to the 75th percentile — and the dot on it is the medianMedianThe middle value once everything is lined up in order, which a few unusually large or small entries cannot drag around.. Beside each name: the median, the middle half and the number of studies both were computed from.

Median actual enrolment, and the middle half around it

participants per registered study

Across 23 modalities the median enrolment ranges from 11.5 (High-intensity electromagnetic muscle stimulation) to 132 (Botulinum toxin (cosmetic)), and the middle half of Topical clascoterone runs 614.5 wide.

0200400600Botulinum toxin (cosmetic)Median enrolment 132 · middle half 45–300 · n = 165Calcium hydroxylapatite fillerMedian enrolment 101 · middle half 62.5–126 · n = 6Bimatoprost for eyelash growthMedian enrolment 79.5 · middle half 32.2–285 · n = 28Poly-L-lactic acid collagen stimulatorMedian enrolment 79.5 · middle half 47.5–193.2 · n = 8Hyaluronic acid fillerMedian enrolment 69.5 · middle half 60–104.8 · n = 34Topical retinoidMedian enrolment 60 · middle half 26–269 · n = 275Topical clascoteroneMedian enrolment 46 · middle half 18–632.5 · n = 16Topical hydroquinone / triple combinationMedian enrolment 32 · middle half 20–56 · n = 34Monopolar RF skin tighteningMedian enrolment 31 · middle half 20.5–70 · n = 6CryolipolysisMedian enrolment 30 · middle half 11.8–49 · n = 14IPL / broadband lightMedian enrolment 30 · middle half 11.8–48.8 · n = 24Mechanical microneedlingMedian enrolment 30 · middle half 12–40 · n = 65Sebaceous-gland laser for acneMedian enrolment 30 · middle half 25–55 · n = 3Ultrasound lifting & tighteningMedian enrolment 30 · middle half 20–90 · n = 9HydradermabrasionMedian enrolment 27 · middle half 21–42 · n = 7Cellulite septa releaseMedian enrolment 22 · middle half 18.5–48 · n = 3Picosecond laser (pigment & tattoo)Median enrolment 21 · middle half 17.2–38 · n = 20Ablative / hybrid fractional laserMedian enrolment 20 · middle half 10–32 · n = 137Laser hair removalMedian enrolment 20 · middle half 20–30 · n = 18Pulsed dye laserMedian enrolment 20 · middle half 6–28 · n = 49Radiofrequency microneedlingMedian enrolment 20 · middle half 12.5–27.2 · n = 28Non-ablative fractional laserMedian enrolment 19 · middle half 10–30 · n = 83High-intensity electromagnetic muscle stimulationMedian enrolment 11.5 · middle half 0–40.5 · n = 4

The bar is the middle half — the 25th to the 75th percentile — and the dot on it is the median. The smallest and largest single studies are deliberately NOT drawn: the largest is 28,700 participants, and plotting it would squash every bar on this chart into a hairline. Both are on every row's tooltip and in the table below. 8 rows drawn at reduced opacity carry fewer than 10 studies that reported an actual count, so the spread shown is computed from very few records. The exact count is printed on every row.

Actual enrolment per modality: the lower quartile, the median, the upper quartile and the number of studies each was computed from
Lower quartileMedian enrolmentUpper quartileRecordsSmallestLargestTotal enrolledReported an enrolment of zero
Botulinum toxin (cosmetic)4513230016502,69136,3103
Calcium hydroxylapatite filler62.51011266201815870
Bimatoprost for eyelash growth32.279.52852801,6995,6241
Poly-L-lactic acid collagen stimulator47.579.5193.28298671,5960
Hyaluronic acid filler6069.5104.83403202,9301
Topical retinoid2660269275028,700101,63012
Topical clascoterone1846632.516107624,1930
Topical hydroquinone / triple combination2032563461501,6310
Monopolar RF skin tightening20.531706122844580
Cryolipolysis11.830491410604560
IPL / broadband light11.83048.82401208091
Mechanical microneedling1230406502022,1432
Sebaceous-gland laser for acne253055320801300
Ultrasound lifting & tightening2030909201294930
Hydradermabrasion212742702574101
Cellulite septa release18.52248315741110
Picosecond laser (pigment & tattoo)17.22138207845650
Ablative / hybrid fractional laser10203213702634,03412
Laser hair removal2020301811484580
Pulsed dye laser620284901501,3289
Radiofrequency microneedling12.52027.2280796741
Non-ablative fractional laser1019308301002,1286
High-intensity electromagnetic muscle stimulation011.540.540931162

The axis stops at 650 participants, so the chart shows the bulk of each modality, not its extremes.

Actual enrolment per modality: the median, the middle half, the range, the total and how many studies reported anything at all. Planned or estimated enrolment is excluded and counted separately.

ModalityMedian actual enrolmentActual enrolmentThe number of people a study finished with, recorded after it ran.25th percentile75th percentileMiddle halfIQRInterquartile range: the stretch covering the middle half of the values, from a quarter of the way up the list to three quarters of the way up.SmallestLargestTotal enrolledStudies with an actual countActual enrolment of zeroEstimated enrolment onlyEstimated enrolmentThe number of people the people running a study expected to recruit, recorded before the answer was known.No count at all
Botulinum toxin (cosmetic)1324530025502,69136,3101653183
Calcium hydroxylapatite filler10162.512663.5201815876010
Bimatoprost for eyelash growth79.532.2285252.801,6995,62428100
Poly-L-lactic acid collagen stimulator79.547.5193.2145.8298671,5968072
Hyaluronic acid filler69.560104.844.803202,930341111
Topical retinoid6026269243028,700101,63027512617
Topical clascoterone4618632.5614.5107624,19316050
Topical hydroquinone / triple combination3220563661501,631340170
Monopolar RF skin tightening3120.57049.5122844586030
Cryolipolysis3011.84937.2106045614060
IPL / broadband light3011.848.8370120809241145
Mechanical microneedling3012402802022,143652700
Sebaceous-gland laser for acne3025553020801303020
Ultrasound lifting & tightening30209070201294939070
Hydradermabrasion2721422102574107120
Cellulite septa release2218.54829.515741113010
Picosecond laser (pigment & tattoo)2117.23820.878456520070
Ablative / hybrid fractional laser2010322202634,03413712920
Laser hair removal202030101148458180102
Pulsed dye laser206282201501,328499185
Radiofrequency microneedling2012.527.214.807967428190
Non-ablative fractional laser1910302001002,128836441
High-intensity electromagnetic muscle stimulation11.5040.540.50931164200

Median participants per registered trial that reported an actual enrolment; small medians mean small studies, not necessarily weak ones.

Results transparency

318 of 913 completed studies have results postedmethod →

Two views of the same rows. “Posting rate” is the share of each modality's COMPLETED registered studies carrying results posted, with the count it came from beside every name; “Completed studies” draws those same studies as counts, so a modality with two completed studies is two studies long.

Completed studies with a results section posted

share of that modality's completed studies

Pooled across every row the results-posting rate is 34.8% (318 of 913); among the 10 modalities with at least 20 records it spans 12.9% to 73.1%.

0%25%50%75%100%34.8% · all rows pooled, 318 of 913Cellulite septa release2 of 2 completed studies100.0%Calcium hydroxylapatite filler5 of 6 completed studies83.3%Ultrasound lifting & tightening6 of 8 completed studies75.0%Topical clascoterone11 of 15 completed studies73.3%Bimatoprost for eyelash growth19 of 26 completed studies73.1%Radiofrequency microneedling15 of 24 completed studies62.5%Topical retinoid111 of 251 completed studies44.2%Botulinum toxin (cosmetic)70 of 160 completed studies43.8%Cryolipolysis5 of 13 completed studies38.5%Poly-L-lactic acid collagen stimulator3 of 8 completed studies37.5%IPL / broadband light5 of 19 completed studies26.3%Hyaluronic acid filler7 of 31 completed studies22.6%Picosecond laser (pigment & tattoo)4 of 18 completed studies22.2%Pulsed dye laser8 of 38 completed studies21.1%Mechanical microneedling12 of 58 completed studies20.7%Non-ablative fractional laser11 of 63 completed studies17.5%Ablative / hybrid fractional laser17 of 108 completed studies15.7%Hydradermabrasion1 of 7 completed studies14.3%Topical hydroquinone / triple combination4 of 31 completed studies12.9%Laser hair removal2 of 16 completed studies12.5%Monopolar RF skin tightening0 of 6 completed studies0.0%Sebaceous-gland laser for acne0 of 3 completed studies0.0%High-intensity electromagnetic muscle stimulation0 of 2 completed studies0.0%

The axis is fixed at 0–100%, never rescaled to the largest value on it. The vertical rule is the pooled rate — every posted result over every completed study, not the average of these rows. 13 rows drawn at reduced opacity carry fewer than 20 completed studies, so the spread shown is computed from very few records. The exact count is printed on every row.

Results-posting rate per modality, with the counts it was computed from
Posted rateCountCompleted studies
Cellulite septa release100.0%22
Calcium hydroxylapatite filler83.3%56
Ultrasound lifting & tightening75.0%68
Topical clascoterone73.3%1115
Bimatoprost for eyelash growth73.1%1926
Radiofrequency microneedling62.5%1524
Topical retinoid44.2%111251
Botulinum toxin (cosmetic)43.8%70160
Cryolipolysis38.5%513
Poly-L-lactic acid collagen stimulator37.5%38
IPL / broadband light26.3%519
Hyaluronic acid filler22.6%731
Picosecond laser (pigment & tattoo)22.2%418
Pulsed dye laser21.1%838
Mechanical microneedling20.7%1258
Non-ablative fractional laser17.5%1163
Ablative / hybrid fractional laser15.7%17108
Hydradermabrasion14.3%17
Topical hydroquinone / triple combination12.9%431
Laser hair removal12.5%216
Monopolar RF skin tightening0.0%06
Sebaceous-gland laser for acne0.0%03
High-intensity electromagnetic muscle stimulation0.0%02

A rate is only as solid as its denominator, so the denominator is printed on every row.

Share of COMPLETED registered studies with a results section posted on ClinicalTrials.gov, with the counts the share was computed from.

ModalityPosted rateResults postedWhether the people who ran a study later uploaded its actual outcome numbers to the public registry, which is a separate step from registering the study in the first place.Completed with resultsCompletedAny status, with resultsRegisteredResults flag missing
Cellulite septa release100%22240
Calcium hydroxylapatite filler83%56570
Ultrasound lifting & tightening75%686160
Topical clascoterone73%111511210
Bimatoprost for eyelash growth73%192619280
Radiofrequency microneedling62%152415370
Topical retinoid44%1112511183430
Botulinum toxin (cosmetic)44%70160711860
Cryolipolysis38%5135200
Poly-L-lactic acid collagen stimulator38%383170
IPL / broadband light26%5199430
Hyaluronic acid filler23%7317460
Picosecond laser (pigment & tattoo)22%4185270
Pulsed dye laser21%83810720
Mechanical microneedling21%1258131350
Non-ablative fractional laser18%1163151280
Ablative / hybrid fractional laser16%17108212290
Hydradermabrasion14%17190
Topical hydroquinone / triple combination13%4315510
Laser hair removal12%2162300
Monopolar RF skin tightening0%06090
Sebaceous-gland laser for acne0%03050
High-intensity electromagnetic muscle stimulation0%02040

Registration is not publication: a low rate means results were not posted to ClinicalTrials.gov, not that the device failed.

Sponsor concentration

23 modalitiesmethod →

Each bar is one modality's registered studies, split by how far down its ranked list of lead sponsors they sit: the largest one, the next four, then everyone else. The first two bands together are that modality's top-five share.

Share of each modality's registered studies held by its largest lead sponsors

share of the studies read for that modality

Largest lead sponsor accounts for 13.6% of the 1,467 studies read pooled, and ranges from 5.9% (Topical hydroquinone / triple combination) to 71.4% (Bimatoprost for eyelash growth) across the 15 modalities with at least 20 records.

0%25%50%75%100%High-intensity electromagnetic muscle stimulation4 studies read100%Bimatoprost for eyelash growth28 studies read71%Calcium hydroxylapatite filler7 studies read71%Cellulite septa release4 studies read50%Monopolar RF skin tightening9 studies read33%Cryolipolysis20 studies read30%Topical clascoterone21 studies read29%Ultrasound lifting & tightening16 studies read25%Hydradermabrasion9 studies read22%Radiofrequency microneedling37 studies read22%Sebaceous-gland laser for acne5 studies read20%Pulsed dye laser72 studies read18%Poly-L-lactic acid collagen stimulator17 studies read18%Picosecond laser (pigment & tattoo)27 studies read15%Botulinum toxin (cosmetic)186 studies read13%IPL / broadband light43 studies read12%Topical retinoid343 studies read11%Laser hair removal30 studies read10%Ablative / hybrid fractional laser229 studies read10%Hyaluronic acid filler46 studies read9%Mechanical microneedling135 studies read8%Non-ablative fractional laser128 studies read8%Topical hydroquinone / triple combination51 studies read6%

Each bar is one modality's own registered studies, so the bars are all the same length and the split is the subject. The number of studies each split was computed from is on every row and in the table below.

Registered studies per modality, split by how far down its ranked list of lead sponsors they sit
Largest lead sponsorNext four largestEvery other lead sponsorStudies read
High-intensity electromagnetic muscle stimulation4004
Bimatoprost for eyelash growth205328
Calcium hydroxylapatite filler5207
Cellulite septa release2204
Monopolar RF skin tightening3429
Cryolipolysis69520
Topical clascoterone613221
Ultrasound lifting & tightening46616
Hydradermabrasion2439
Radiofrequency microneedling8121737
Sebaceous-gland laser for acne1405
Pulsed dye laser13144572
Poly-L-lactic acid collagen stimulator38617
Picosecond laser (pigment & tattoo)491427
Botulinum toxin (cosmetic)2447115186
IPL / broadband light5112743
Topical retinoid3761245343
Laser hair removal352230
Ablative / hybrid fractional laser2240167229
Hyaluronic acid filler4113146
Mechanical microneedling1123101135
Non-ablative fractional laser102395128
Topical hydroquinone / triple combination393951

Concentration is a fact about how few organisations the evidence rests on — not a verdict on a treatment.

How few organisations the registered evidence rests on, per modality, with the single largest lead sponsor named.

ModalityStudies readDistinct lead sponsorsLargest lead sponsorLead sponsorThe organisation that takes responsibility for a study, which may be a manufacturer, a hospital, a university or a government body.Its classIts studiesLargest sponsor's shareSponsor concentrationHow much of a group of studies sits with the single busiest organisation rather than being spread across many.Largest five sponsors' shareSponsor unnamed
High-intensity electromagnetic muscle stimulation41BTL Industries Ltd.INDUSTRY4100%100%0
Bimatoprost for eyelash growth288AllerganINDUSTRY2071%89%0
Calcium hydroxylapatite filler73Merz North America, Inc.INDUSTRY571%100%0
Cellulite septa release43Northwestern UniversityOTHER250%100%0
Monopolar RF skin tightening97CLASSYS Inc.INDUSTRY333%78%0
Cryolipolysis2010Cairo UniversityOTHER630%75%0
Topical clascoterone217Cassiopea SpAINDUSTRY629%90%0
Ultrasound lifting & tightening1611Ulthera, IncINDUSTRY425%62%0
Hydradermabrasion98University of MichiganOTHER222%67%0
Radiofrequency microneedling3722Venus ConceptINDUSTRY822%54%0
Sebaceous-gland laser for acne55ConBio, a Cynosure CompanyINDUSTRY120%100%0
Pulsed dye laser7242University of California, IrvineOTHER1318%38%0
Poly-L-lactic acid collagen stimulator1711Bausch Health Americas, Inc.INDUSTRY318%65%0
Picosecond laser (pigment & tattoo)2719Cutera Inc.INDUSTRY415%48%0
Botulinum toxin (cosmetic)18669AllerganINDUSTRY2413%38%0
IPL / broadband light4331Bispebjerg HospitalOTHER512%37%0
Topical retinoid343169Galderma R&DINDUSTRY3711%29%0
Laser hair removal3027Cynosure, Inc.INDUSTRY310%27%0
Ablative / hybrid fractional laser229131Assiut UniversityOTHER2210%27%0
Hyaluronic acid filler4630LG ChemINDUSTRY49%33%0
Mechanical microneedling13585Assiut UniversityOTHER118%25%0
Non-ablative fractional laser12870Bispebjerg HospitalOTHER108%26%0
Topical hydroquinone / triple combination5140Dr.dr.Irma Bernadette, SpKK (K)OTHER36%24%0

Every modality's five largest lead sponsors, exactly as the registry spells them.

ModalityRankLead sponsorClassStudiesShare of that modality
High-intensity electromagnetic muscle stimulation1BTL Industries Ltd.INDUSTRY4100%
Bimatoprost for eyelash growth1AllerganINDUSTRY2071%
Bimatoprost for eyelash growth2Duke UniversityOTHER27%
Bimatoprost for eyelash growth3ATS Clinical ResearchOTHER14%
Bimatoprost for eyelash growth4Ahmed Hassan Nouh MDOTHER14%
Bimatoprost for eyelash growth5Jonsson Comprehensive Cancer CenterOTHER14%
Calcium hydroxylapatite filler1Merz North America, Inc.INDUSTRY571%
Calcium hydroxylapatite filler2AQTIS Medical B.V.OTHER114%
Calcium hydroxylapatite filler3University of California, IrvineOTHER114%
Cellulite septa release1Northwestern UniversityOTHER250%
Cellulite septa release2Cairo UniversityOTHER125%
Cellulite septa release3Revelle Aesthetics, IncINDUSTRY125%
Monopolar RF skin tightening1CLASSYS Inc.INDUSTRY333%
Monopolar RF skin tightening2CynosureLutronicINDUSTRY111%
Monopolar RF skin tightening3Lorraine HicksonOTHER111%
Monopolar RF skin tightening4Seoul National University Bundang HospitalOTHER111%
Monopolar RF skin tightening5TENTECH INC.INDUSTRY111%
Cryolipolysis1Cairo UniversityOTHER630%
Cryolipolysis2Zeltiq AestheticsINDUSTRY630%
Cryolipolysis3Federal University of Health Science of Porto AlegreOTHER15%
Cryolipolysis4Laser and Skin Surgery Center of New YorkOTHER15%
Cryolipolysis5Massachusetts General HospitalOTHER15%
Topical clascoterone1Cassiopea SpAINDUSTRY629%
Topical clascoterone2Sun Pharmaceutical Industries LimitedINDUSTRY629%
Topical clascoterone3Intrepid Therapeutics, Inc.INDUSTRY314%
Topical clascoterone4Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd.INDUSTRY314%
Topical clascoterone5Khyber Teaching HospitalOTHER15%
Ultrasound lifting & tightening1Ulthera, IncINDUSTRY425%
Ultrasound lifting & tightening2Merz North America, Inc.INDUSTRY212%
Ultrasound lifting & tightening3Northwestern UniversityOTHER212%
Ultrasound lifting & tightening4Goldman, Butterwick, Fitzpatrick and GroffOTHER16%
Ultrasound lifting & tightening5Nashville Centre for Laser and Facial SurgeryOTHER16%
Hydradermabrasion1University of MichiganOTHER222%
Hydradermabrasion2Assiut UniversityOTHER111%
Hydradermabrasion3Austin Institute for Clinical ResearchNETWORK111%
Hydradermabrasion4Beauty HealthINDUSTRY111%
Hydradermabrasion5Bispebjerg HospitalOTHER111%
Radiofrequency microneedling1Venus ConceptINDUSTRY822%
Radiofrequency microneedling2Cynosure, Inc.INDUSTRY514%
Radiofrequency microneedling3University of Texas Southwestern Medical CenterOTHER38%
Radiofrequency microneedling4Goldman, Butterwick, Fitzpatrick and GroffOTHER25%
Radiofrequency microneedling5Syneron MedicalINDUSTRY25%
Sebaceous-gland laser for acne1ConBio, a Cynosure CompanyINDUSTRY120%
Sebaceous-gland laser for acne2Cutera Inc.INDUSTRY120%
Sebaceous-gland laser for acne3Erasmus Medical CenterOTHER120%
Sebaceous-gland laser for acne4Laserklinik KarlsruheOTHER120%
Sebaceous-gland laser for acne5Wynn Medical CenterOTHER120%
Pulsed dye laser1University of California, IrvineOTHER1318%
Pulsed dye laser2Bispebjerg HospitalOTHER46%
Pulsed dye laser3Cairo UniversityOTHER46%
Pulsed dye laser4Centre Hospitalier Universitaire de NiceOTHER34%
Pulsed dye laser5Northwestern UniversityOTHER34%
Poly-L-lactic acid collagen stimulator1Bausch Health Americas, Inc.INDUSTRY318%
Poly-L-lactic acid collagen stimulator2Goldman, Butterwick, Fitzpatrick and GroffOTHER318%
Poly-L-lactic acid collagen stimulator3Galderma R&DINDUSTRY212%
Poly-L-lactic acid collagen stimulator4Sadick Research GroupOTHER212%
Poly-L-lactic acid collagen stimulator5DermAvanceINDUSTRY16%
Picosecond laser (pigment & tattoo)1Cutera Inc.INDUSTRY415%
Picosecond laser (pigment & tattoo)2Syneron MedicalINDUSTRY311%
Picosecond laser (pigment & tattoo)3Focus Medical, LLCINDUSTRY27%
Picosecond laser (pigment & tattoo)4Goldman, Butterwick, Fitzpatrick and GroffOTHER27%
Picosecond laser (pigment & tattoo)5Mahidol UniversityOTHER27%
Botulinum toxin (cosmetic)1AllerganINDUSTRY2413%
Botulinum toxin (cosmetic)2Revance Therapeutics, Inc.INDUSTRY1910%
Botulinum toxin (cosmetic)3Galderma R&DINDUSTRY137%
Botulinum toxin (cosmetic)4Medy-ToxINDUSTRY84%
Botulinum toxin (cosmetic)5Eirion Therapeutics Inc.INDUSTRY74%
IPL / broadband light1Bispebjerg HospitalOTHER512%
IPL / broadband light2Lumenis Be Ltd.INDUSTRY37%
IPL / broadband light3ScitonINDUSTRY37%
IPL / broadband light4Venus ConceptINDUSTRY37%
IPL / broadband light5Mayo ClinicOTHER25%
Topical retinoid1Galderma R&DINDUSTRY3711%
Topical retinoid2Stiefel, a GSK CompanyINDUSTRY247%
Topical retinoid3Bausch Health Americas, Inc.INDUSTRY175%
Topical retinoid4Sun Pharmaceutical Industries, Inc.INDUSTRY113%
Topical retinoid5Assiut UniversityOTHER93%
Laser hair removal1Cynosure, Inc.INDUSTRY310%
Laser hair removal2Erasmus Medical CenterOTHER27%
Laser hair removal3Alexandria UniversityOTHER13%
Laser hair removal4BayerINDUSTRY13%
Laser hair removal5Bispebjerg HospitalOTHER13%
Ablative / hybrid fractional laser1Assiut UniversityOTHER2210%
Ablative / hybrid fractional laser2Cairo UniversityOTHER167%
Ablative / hybrid fractional laser3Bispebjerg HospitalOTHER94%
Ablative / hybrid fractional laser4Netherlands Institute for Pigment DisordersOTHER84%
Ablative / hybrid fractional laser5Massachusetts General HospitalOTHER73%
Hyaluronic acid filler1LG ChemINDUSTRY49%
Hyaluronic acid filler2Merz North America, Inc.INDUSTRY49%
Hyaluronic acid filler3Jetema Co., Ltd.INDUSTRY36%
Hyaluronic acid filler4Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)OTHER24%
Hyaluronic acid filler5Bohus Biotech ABINDUSTRY24%
Mechanical microneedling1Assiut UniversityOTHER118%
Mechanical microneedling2Sohag UniversityOTHER86%
Mechanical microneedling3Alexandria UniversityOTHER54%
Mechanical microneedling4Cynosure, Inc.INDUSTRY54%
Mechanical microneedling5Zagazig UniversityOTHER_GOV54%
Non-ablative fractional laser1Bispebjerg HospitalOTHER108%
Non-ablative fractional laser2Netherlands Institute for Pigment DisordersOTHER86%
Non-ablative fractional laser3Cairo UniversityOTHER54%
Non-ablative fractional laser4Dong-A UniversityOTHER54%
Non-ablative fractional laser5Massachusetts General HospitalOTHER54%
Topical hydroquinone / triple combination1Dr.dr.Irma Bernadette, SpKK (K)OTHER36%
Topical hydroquinone / triple combination2Galderma R&DINDUSTRY36%
Topical hydroquinone / triple combination3Cosmetique Active InternationalINDUSTRY24%
Topical hydroquinone / triple combination4Cynosure, Inc.INDUSTRY24%
Topical hydroquinone / triple combination5Indonesia UniversityOTHER24%

Sponsor names are the registry's raw lead-sponsor strings — this site does not merge them, so one company spelled two ways counts twice.

Still being studied

started on or after 2021-07-26method →

Each bar is one modality's registered studies, split three ways by start date: on or after 2021-07-26, before it, or no start date the run could parse. The three parts are the whole.

When each modality's registered studies started

share of that modality's registered studies

Started in the last 5 years accounts for 33.3% of the 1,467 registered studies pooled, and ranges from 0.0% (Bimatoprost for eyelash growth) to 66.7% (Topical clascoterone) across the 15 modalities with at least 20 records.

0%25%50%75%100%Monopolar RF skin tightening9 registered studies89%Topical clascoterone21 registered studies67%Mechanical microneedling135 registered studies64%Poly-L-lactic acid collagen stimulator17 registered studies47%Topical hydroquinone / triple combination51 registered studies49%Hyaluronic acid filler46 registered studies41%Radiofrequency microneedling37 registered studies41%Sebaceous-gland laser for acne5 registered studies40%IPL / broadband light43 registered studies37%Ablative / hybrid fractional laser229 registered studies35%Picosecond laser (pigment & tattoo)27 registered studies33%Ultrasound lifting & tightening16 registered studies31%Botulinum toxin (cosmetic)186 registered studies30%Cryolipolysis20 registered studies30%Non-ablative fractional laser128 registered studies27%Cellulite septa release4 registered studies25%Topical retinoid343 registered studies24%Laser hair removal30 registered studies23%Hydradermabrasion9 registered studies22%Calcium hydroxylapatite filler7 registered studies14%Pulsed dye laser72 registered studies12%Bimatoprost for eyelash growth28 registered studiesHigh-intensity electromagnetic muscle stimulation4 registered studies

The three parts are the whole: every registered study this run read is in exactly one of them, and a study whose start date could not be parsed is its own class rather than being folded into “earlier”.

Registered studies per modality by start date: within the last five years, earlier, or no parseable date
Started in the last 5 yearsStarted earlierStart date unknownRegistered studies
Monopolar RF skin tightening8109
Topical clascoterone147021
Mechanical microneedling87480135
Poly-L-lactic acid collagen stimulator88117
Topical hydroquinone / triple combination2526051
Hyaluronic acid filler1927046
Radiofrequency microneedling1522037
Sebaceous-gland laser for acne2305
IPL / broadband light1626143
Ablative / hybrid fractional laser811480229
Picosecond laser (pigment & tattoo)918027
Ultrasound lifting & tightening511016
Botulinum toxin (cosmetic)561300186
Cryolipolysis614020
Non-ablative fractional laser34940128
Cellulite septa release1304
Topical retinoid832591343
Laser hair removal723030
Hydradermabrasion2709
Calcium hydroxylapatite filler1607
Pulsed dye laser962172
Bimatoprost for eyelash growth028028
High-intensity electromagnetic muscle stimulation0404

An old evidence base is not automatically a weak one — a settled technique may simply have stopped needing new trials.

Share of each modality's registered studies that started within the last five years, with the counts behind it.

An old evidence base is not automatically a weak one — a settled technique may simply have stopped needing new trials.

What the literature is made of

25 modalities · 6 publication types · 2 windowsmethod →

One row per modality, four dots on it: each dot is one publication type as a share of that modality's own PubMed total, and the total is printed beside the name. The dots are separate marks, not a stacked bar, because these types overlap and do not sum to the total. Every count, including the three types the chart does not draw, is in the table under each chart.

Publication types as a share of each modality's own total

share of that modality's PubMed records

Pooled across every row the case-report share is 10.2% (1,956 of 19,202); among the 21 modalities with at least 100 records it spans 2.4% to 18.9%.

0%10%20%30%Topical retinoid4,253 recordsBotulinum toxin (cosmetic)2,201 recordsPulsed dye laser1,530 recordsAblative / hybrid fractional laser1,485 recordsHyaluronic acid filler1,299 recordsNon-ablative fractional laser1,158 recordsTopical hydroquinone / triple combination1,116 recordsIPL / broadband light1,028 recordsLaser hair removal744 recordsMechanical microneedling620 recordsPoly-L-lactic acid collagen stimulator586 recordsCalcium hydroxylapatite filler582 recordsMonopolar RF skin tightening432 recordsRadiofrequency microneedling354 recordsPicosecond laser (pigment & tattoo)323 recordsUltrasound lifting & tightening317 recordsRF body contouring255 recordsCryolipolysis245 recordsHydradermabrasion166 recordsBimatoprost for eyelash growth128 recordsNon-invasive laser lipolysis112 recordsTopical clascoterone90 recordsSebaceous-gland laser for acne67 recordsHigh-intensity electromagnetic muscle stimulation61 recordsCellulite septa release50 records

These four types OVERLAP and do not sum to the total: a record typed as a randomised controlled trial is also inside clinical trials of any type, and records carrying no publication type at all are in none of them. Each dot is that type's share of the modality's own total, and the total is on every row. No lower date bound. Whatever PubMed has indexed, back to the start of the record.

PubMed records by publication type, all time, as counts
Systematic reviews or meta-analysesRandomised controlled trialsClinical trials, any typeCase reportsRecords
Topical retinoid904316592694,253
Botulinum toxin (cosmetic)1142483132002,201
Pulsed dye laser781182052871,530
Ablative / hybrid fractional laser742333311631,485
Hyaluronic acid filler411622091931,299
Non-ablative fractional laser461882651141,158
Topical hydroquinone / triple combination33143182891,116
IPL / broadband light63122184861,028
Laser hair removal295695126744
Mechanical microneedling51597038620
Poly-L-lactic acid collagen stimulator21385277586
Calcium hydroxylapatite filler38273882582
Monopolar RF skin tightening8328018432
Radiofrequency microneedling25527921354
Picosecond laser (pigment & tattoo)11425461323
Ultrasound lifting & tightening14284425317
RF body contouring7123914255
Cryolipolysis16143427245
Hydradermabrasion212194166
Bimatoprost for eyelash growth3202522128
Non-invasive laser lipolysis182010112
Topical clascoterone8816890
Sebaceous-gland laser for acne226867
High-intensity electromagnetic muscle stimulation237561
Cellulite septa release213950

Counting study types is not a quality assessment, and these rows overlap — never add them.

PubMed records by publication type, all time. No lower date bound. Whatever PubMed has indexed, back to the start of the record. The filtered rows are subsets of the total and overlap each other: they do not sum to it.

ModalityTotalSystematic reviews or meta-analysesSystematic reviewA paper that hunts down every study on one question using a search method it states up front, then summarises what the whole set shows.Randomised controlled trialsRandomised controlled trialA study that decides by chance which participants get which treatment, so that the groups being compared start out alike and a difference at the end is easier to pin on the treatment.Either of those twoHigher-tier evidenceThis site's shorthand for the pooled papers and the randomised trials counted together in one search, so a paper carrying both labels is only counted once.Clinical trials, any typeClinical trialA broad label covering studies of many designs that test a treatment in people, which is why it always contains the randomised ones rather than sitting alongside them.Reviews, any typeReviewA paper that surveys a topic in the author's own framing and contains no new patients of its own.Case reportsCase reportA write-up of one patient, or a small handful, described after the fact — useful as a sign that something can happen, and no guide at all to how often it does.Case reports, share of totalEither of those two, share of total
Topical retinoid4,253904315216597162696%12%
Botulinum toxin (cosmetic)2,2011142483623136602009%16%
Pulsed dye laser1,5307811819620527728719%13%
Ablative / hybrid fractional laser1,4857423330733119416311%21%
Hyaluronic acid filler1,2994116220320919019315%16%
Non-ablative fractional laser1,1584618823426518911410%20%
Topical hydroquinone / triple combination1,11633143176182189898%16%
IPL / broadband light1,02863122185184258868%18%
Laser hair removal7442956859512612617%11%
Mechanical microneedling620515911070178386%18%
Poly-L-lactic acid collagen stimulator586213859521457713%10%
Calcium hydroxylapatite filler582382765381448214%11%
Monopolar RF skin tightening432832408084184%9%
Radiofrequency microneedling3542552777968216%22%
Picosecond laser (pigment & tattoo)32311425354316119%16%
Ultrasound lifting & tightening3171428424478258%13%
RF body contouring255712193963146%8%
Cryolipolysis24516143034542711%12%
Hydradermabrasion16621214195442%8%
Bimatoprost for eyelash growth1283202325302217%18%
Non-invasive laser lipolysis1121892017109%8%
Topical clascoterone908816164389%18%
Sebaceous-gland laser for acne67224616812%6%
High-intensity electromagnetic muscle stimulation612357758%8%
Cellulite septa release50213313918%6%

Counting study types is not a quality assessment, and these rows overlap — never add them.

Carried by case reports

8 modalities

Modalities whose all-time literature contains more case reports than randomised trials and systematic reviews combined. all_time.rows.case_reports.count > all_time.rows.higher_tier_union.count

ModalityTotal recordsCase reportsTrials or syst. reviewsCase-report share
Picosecond laser (pigment & tattoo)323615319%
Pulsed dye laser1,53028719619%
Cellulite septa release509318%
Laser hair removal7441268517%
Calcium hydroxylapatite filler582826514%
Poly-L-lactic acid collagen stimulator586775913%
Sebaceous-gland laser for acne678412%
Non-invasive laser lipolysis1121099%

A case report is one patient written up after the fact — a signal, not evidence of an average effect.

The queries, verbatim

re-runnable · pt-v1-2026-07-26method →

The publication-type clause appended to each modality's base query, one row per split. The same clause is used for every modality and both windows.

RowClause appendedWhat it is
totalnone — the unfiltered queryThe unfiltered modality query. Every other row on this modality is a strict subset of it.
systematic_review_meta_analysis AND (systematic[sb] OR "meta-analysis"[pt])PubMed's systematic-review subset OR records typed Meta-Analysis. systematic[sb] is a curated NLM search strategy, not a publication type, so it also catches some reviews of systematic reviews and some protocols.
randomized_controlled_trial AND "randomized controlled trial"[pt]Records typed Randomized Controlled Trial. Says nothing about sample size, blinding, comparator quality, follow-up length or whether the result was positive.
clinical_trial_any AND "clinical trial"[pt]Records typed Clinical Trial. PubMed explodes this type, so it INCLUDES the randomized controlled trial row plus controlled and phase I-IV trials. Do not add it to the RCT row.
review AND "review"[pt]Records typed Review: narrative reviews, expert overviews. A review contains no new patients. High review counts mean a topic is much discussed, not much tested.
case_reports AND "case reports"[pt]Records typed Case Reports: one patient, or a handful, described after the fact. Often a complication or an unusual response. Valuable as a signal, worthless as evidence of average effect.
higher_tier_union AND ((systematic[sb] OR "meta-analysis"[pt]) OR "randomized controlled trial"[pt])Fetched union of the systematic-review/meta-analysis row and the RCT row. Fetched, not added: a record can carry both types, so summing the two rows would double-count. This is the de-duplicated number.

PubMed, per modality

25 base queries

Every modality's base PubMed query, read verbatim from the study record and never rewritten. Each publication-type row is this query with one clause appended.

ModalityBase query, all timeLive count
Ablative / hybrid fractional laser("ablative fractional"[tiab] OR "fractional CO2"[tiab] OR "fractional carbon dioxide"[tiab] OR "fractional erbium"[tiab] OR "erbium:YAG"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR resurfacing[tiab] OR wrinkle*[tiab] OR scar*[tiab] OR rejuvenation[tiab])run it
Bimatoprost for eyelash growth(bimatoprost[tiab] OR "prostaglandin analog"[tiab]) AND (eyelash*[tiab] OR hypotrichosis[tiab] OR "lash growth"[tiab])run it
Botulinum toxin (cosmetic)("botulinum toxin"[tiab] OR onabotulinumtoxinA[tiab] OR abobotulinumtoxinA[tiab] OR incobotulinumtoxinA[tiab] OR prabotulinumtoxinA[tiab] OR daxibotulinumtoxinA[tiab]) AND ("glabellar"[tiab] OR "crow's feet"[tiab] OR "lateral canthal"[tiab] OR "forehead lines"[tiab] OR rhytid*[tiab] OR wrinkle*[tiab] OR cosmetic[tiab] OR aesthetic[tiab])run it
Calcium hydroxylapatite filler("calcium hydroxylapatite"[tiab] OR "calcium hydroxyapatite"[tiab]) AND ("dermal filler"[tiab] OR "soft tissue"[tiab] OR facial[tiab] OR aesthetic[tiab] OR cosmetic[tiab] OR skin[tiab] OR nasolabial[tiab])run it
Cellulite septa release(("cellulite"[tiab]) AND (subcision[tiab] OR "septa release"[tiab] OR "tissue stabilized"[tiab] OR "manual subcision"[tiab] OR "targeted verifiable subcision"[tiab])) OR ("cellulite subcision"[tiab])run it
Cryolipolysis("cryolipolysis"[tiab] OR "cryolipolisis"[tiab] OR "cold-induced lipolysis"[tiab]) AND (fat[tiab] OR adipos*[tiab] OR "body contouring"[tiab] OR subcutaneous[tiab] OR abdomen[tiab] OR flank*[tiab])run it
High-intensity electromagnetic muscle stimulation("high-intensity focused electromagnetic"[tiab] OR "HIFEM"[tiab] OR "high intensity focused electromagnetic"[tiab] OR ("electromagnetic"[tiab] AND "muscle stimulation"[tiab] AND "body contouring"[tiab])) AND (muscle*[tiab] OR abdomen[tiab] OR buttock*[tiab] OR "body contouring"[tiab] OR fat[tiab])run it
Hyaluronic acid filler("hyaluronic acid filler"[tiab] OR "hyaluronic acid dermal filler"[tiab] OR ("hyaluronic acid"[tiab] AND ("dermal filler"[tiab] OR "soft tissue filler"[tiab] OR "nasolabial"[tiab] OR "lip augmentation"[tiab] OR "midface"[tiab]))) AND (aesthetic[tiab] OR cosmetic[tiab] OR facial[tiab] OR skin[tiab] OR volume[tiab])run it
Hydradermabrasion(hydradermabrasion[tiab] OR "hydrafacial"[tiab] OR "hydro-dermabrasion"[tiab] OR ("microdermabrasion"[tiab] AND skin[tiab])) AND (skin[tiab] OR facial[tiab] OR acne[tiab] OR rejuvenation[tiab] OR photoaging[tiab])run it
IPL / broadband light("intense pulsed light"[tiab] OR "broadband light"[tiab] OR IPL[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR photoaging[tiab] OR rosacea[tiab] OR pigmentation[tiab] OR rejuvenation[tiab] OR "hair removal"[tiab])run it
Laser hair removal("laser hair removal"[tiab] OR "laser epilation"[tiab] OR "photoepilation"[tiab] OR ("alexandrite"[tiab] AND hair[tiab]) OR ("diode laser"[tiab] AND "hair removal"[tiab])) AND (skin[tiab] OR hair[tiab] OR cutaneous[tiab])run it
Mechanical microneedling("microneedling"[tiab] OR "micro-needling"[tiab] OR "percutaneous collagen induction"[tiab] OR "dermaroller"[tiab] OR "dermapen"[tiab]) NOT ("radiofrequency"[tiab] OR "microneedle patch"[tiab] OR "vaccine"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR scar*[tiab] OR wrinkle*[tiab] OR rejuvenation[tiab])run it
Monopolar RF skin tightening("monopolar radiofrequency"[tiab] OR "radiofrequency tightening"[tiab] OR ("radiofrequency"[tiab] AND "skin laxity"[tiab]) OR ("radiofrequency"[tiab] AND "skin tightening"[tiab])) AND (skin[tiab] OR cutaneous[tiab] OR face[tiab] OR facial[tiab])run it
Non-ablative fractional laser("nonablative fractional"[tiab] OR "non-ablative fractional"[tiab] OR "fractional photothermolysis"[tiab] OR "fractional laser"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR wrinkle*[tiab] OR rhytid*[tiab] OR scar*[tiab] OR photoaging[tiab] OR rejuvenation[tiab])run it
Non-invasive laser lipolysis(("1060 nm"[tiab] OR "1,060 nm"[tiab] OR "hyperthermic laser"[tiab] OR "laser lipolysis"[tiab] OR "low-level laser"[tiab]) AND (lipolysis[tiab] OR "fat reduction"[tiab] OR "body contouring"[tiab] OR adipocyte*[tiab])) AND (noninvasive[tiab] OR non-invasive[tiab] OR subcutaneous[tiab] OR abdomen[tiab] OR flank*[tiab] OR skin[tiab])run it
Picosecond laser (pigment & tattoo)("picosecond laser"[tiab] OR "picosecond-domain"[tiab] OR "pico laser"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR tattoo*[tiab] OR pigment*[tiab] OR melasma[tiab] OR lentig*[tiab] OR rejuvenation[tiab])run it
Poly-L-lactic acid collagen stimulator("poly-L-lactic acid"[tiab] OR "polylactic acid"[tiab] OR "PLLA"[tiab]) AND (facial[tiab] OR aesthetic[tiab] OR cosmetic[tiab] OR "dermal filler"[tiab] OR lipoatrophy[tiab] OR "collagen stimulat"[tiab] OR nasolabial[tiab])run it
Pulsed dye laser("pulsed dye laser"[tiab] OR "pulsed-dye laser"[tiab] OR "595 nm"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR "port wine"[tiab] OR telangiectas*[tiab] OR rosacea[tiab] OR scar*[tiab] OR vascular[tiab])run it
Radiofrequency microneedling("radiofrequency microneedling"[tiab] OR "microneedle radiofrequency"[tiab] OR "fractional radiofrequency"[tiab] OR "microneedling radiofrequency"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR wrinkle*[tiab] OR rhytid*[tiab] OR scar*[tiab] OR laxity[tiab] OR rejuvenation[tiab])run it
RF body contouring(("radiofrequency"[tiab] OR "radio-frequency"[tiab]) AND ("body contouring"[tiab] OR "fat reduction"[tiab] OR "circumference reduction"[tiab] OR cellulite[tiab] OR adipos*[tiab])) AND (noninvasive[tiab] OR non-invasive[tiab] OR abdomen[tiab] OR flank*[tiab] OR thigh*[tiab] OR skin[tiab])run it
Sebaceous-gland laser for acne(("1726 nm"[tiab] OR "1,726 nm"[tiab] OR "sebaceous gland"[tiab] OR "sebum suppression"[tiab]) AND laser[tiab]) AND (acne[tiab] OR skin[tiab] OR cutaneous[tiab])run it
Topical clascoterone(clascoterone[tiab] OR "cortexolone 17"[tiab] OR "androgen receptor inhibitor"[tiab]) AND (acne[tiab] OR skin[tiab] OR cutaneous[tiab] OR "androgenetic alopecia"[tiab])run it
Topical hydroquinone / triple combination(hydroquinone[tiab] OR "triple combination cream"[tiab] OR "fluocinolone acetonide"[tiab]) AND (melasma[tiab] OR "hyperpigmentation"[tiab] OR "post-inflammatory hyperpigmentation"[tiab] OR skin[tiab] OR "skin lightening"[tiab])run it
Topical retinoid("topical tretinoin"[tiab] OR "topical retinoid"[tiab] OR "retinoic acid"[tiab] OR adapalene[tiab] OR tazarotene[tiab] OR "retinol"[tiab]) AND (skin[tiab] OR cutaneous[tiab] OR acne[tiab] OR photoaging[tiab] OR wrinkle*[tiab] OR melasma[tiab])run it
Ultrasound lifting & tightening("microfocused ultrasound"[tiab] OR "micro-focused ultrasound"[tiab] OR "intense focused ultrasound"[tiab] OR ("ultrasound"[tiab] AND "skin tightening"[tiab]) OR ("ultrasound"[tiab] AND "skin laxity"[tiab])) AND (skin[tiab] OR face[tiab] OR facial[tiab] OR neck[tiab] OR cutaneous[tiab])run it

ClinicalTrials.gov, per modality

1,467 registered studies read

Every modality's ClinicalTrials.gov query, reused character-for-character from the study record. Fields requested: NCTId, LeadSponsorName, LeadSponsorClass, EnrollmentCount, EnrollmentType, OverallStatus, StartDate, HasResults.

ModalityInterventionConditionLive request
Ablative / hybrid fractional laser("ablative fractional laser" OR "fractional CO2 laser" OR "carbon dioxide laser" OR "erbium YAG laser")(skin OR wrinkles OR scars OR photoaging OR rejuvenation OR resurfacing)run it
Bimatoprost for eyelash growth(bimatoprost)("eyelash hypotrichosis" OR eyelashes OR hypotrichosis OR cosmetic)run it
Botulinum toxin (cosmetic)("botulinum toxin" OR onabotulinumtoxinA OR abobotulinumtoxinA OR incobotulinumtoxinA OR daxibotulinumtoxinA)("glabellar lines" OR "facial wrinkles" OR rhytides OR "crow's feet" OR cosmetic)run it
Calcium hydroxylapatite filler("calcium hydroxylapatite" OR "calcium hydroxyapatite filler")("nasolabial folds" OR "facial wrinkles" OR "skin laxity" OR "hand augmentation" OR cosmetic)run it
Cellulite septa release(subcision OR "tissue stabilized subcision" OR "cellulite release")(cellulite OR "edematous fibrosclerotic panniculopathy" OR cosmetic)run it
Cryolipolysis(cryolipolysis OR "cold-induced lipolysis")("body contouring" OR "subcutaneous fat" OR "abdominal fat" OR obesity OR cosmetic)run it
High-intensity electromagnetic muscle stimulation("HIFEM" OR "high intensity focused electromagnetic" OR "electromagnetic muscle stimulation")("body contouring" OR "muscle strengthening" OR "abdominal fat" OR cosmetic OR "body composition")run it
Hyaluronic acid filler("hyaluronic acid filler" OR "hyaluronic acid dermal filler" OR "HA filler")("nasolabial folds" OR "facial wrinkles" OR "lip augmentation" OR "volume deficit" OR cosmetic)run it
Hydradermabrasion(hydradermabrasion OR hydrafacial OR microdermabrasion)(skin OR acne OR "facial rejuvenation" OR photoaging OR cosmetic)run it
IPL / broadband light("intense pulsed light" OR "broadband light" OR IPL)(skin OR photoaging OR rosacea OR pigmentation OR rejuvenation OR hirsutism)run it
Laser hair removal("laser hair removal" OR "laser epilation" OR photoepilation OR "alexandrite laser" OR "diode laser hair")(hirsutism OR "unwanted hair" OR "hair removal" OR pseudofolliculitis OR skin)run it
Mechanical microneedling(microneedling OR "percutaneous collagen induction" OR dermaroller)("acne scars" OR scars OR skin OR wrinkles OR rejuvenation OR melasma)run it
Monopolar RF skin tightening("monopolar radiofrequency" OR "radiofrequency skin tightening")("skin laxity" OR wrinkles OR skin OR rejuvenation OR cellulite)run it
Non-ablative fractional laser("nonablative fractional laser" OR "fractional photothermolysis" OR "fractional laser")(skin OR wrinkles OR scars OR photoaging OR rejuvenation OR melasma)run it
Non-invasive laser lipolysis("laser lipolysis" OR "1060 nm laser" OR "low level laser fat reduction")("body contouring" OR "subcutaneous fat" OR "fat reduction" OR cosmetic)run it
Picosecond laser (pigment & tattoo)("picosecond laser")(tattoo OR melasma OR pigmentation OR lentigines OR acne scars OR skin)run it
Poly-L-lactic acid collagen stimulator("poly-L-lactic acid" OR "injectable poly-L-lactic acid")("facial lipoatrophy" OR "nasolabial folds" OR "facial wrinkles" OR cellulite OR cosmetic)run it
Pulsed dye laser("pulsed dye laser")("port wine stain" OR rosacea OR telangiectasia OR hemangioma OR scars OR skin)run it
Radiofrequency microneedling("radiofrequency microneedling" OR "microneedle radiofrequency" OR "fractional radiofrequency")(skin OR wrinkles OR "acne scars" OR "skin laxity" OR rejuvenation)run it
RF body contouring("radiofrequency body contouring" OR "radiofrequency fat reduction" OR "radiofrequency lipolysis")("body contouring" OR "subcutaneous fat" OR cellulite OR cosmetic)run it
Sebaceous-gland laser for acne("1726 nm laser" OR "sebaceous gland laser" OR "laser treatment of acne")("acne vulgaris" OR acne OR skin)run it
Topical clascoterone(clascoterone OR "cortexolone 17 alpha-propionate")("acne vulgaris" OR acne OR "androgenetic alopecia" OR skin)run it
Topical hydroquinone / triple combination(hydroquinone OR "triple combination cream")(melasma OR hyperpigmentation OR "skin pigmentation" OR skin)run it
Topical retinoid(tretinoin OR "topical retinoid" OR adapalene OR tazarotene OR retinol)("acne vulgaris" OR photoaging OR "facial wrinkles" OR melasma OR skin)run it
Ultrasound lifting & tightening("microfocused ultrasound" OR "micro-focused ultrasound" OR "intense focused ultrasound")("skin laxity" OR wrinkles OR "facial rejuvenation" OR skin OR cosmetic)run it

Every count on this page can be re-run: the query that produced it is printed above, and its live URL is one click away.