Dalphene Index

Every aesthetic device, on the public record

FDA clearances and what each was cleared to treat, a decade of published research, who paid for the trials, and side-by-side comparisons — for 130 lasers, injectables and body systems. Free, no sponsored listings.

136Devices indexed
231Clearances tracked
29Techniques with evidence
75Manufacturer names

Counts of records in this index, not of the US market.

Clearances per month

narrow aesthetic codes · Aug 2025 – Jun 2026

05101520AugOctDecFebAprJun
510(k) clearances per full month, narrow codes, by category
Lasers & LightBody ContouringSkin & TopicalsRF & MicroneedlingTotal
Aug60028
Sep60017
Oct1300316
Nov60006
Dec1130014
Jan40015
Feb31015
Mar70029
Apr21014
May42017
Jun90009

510(k) decisions per month in unambiguously aesthetic codes — filing tempo, not adoption.

Cleared recently

Newest first, narrow aesthetic product codes only
DeviceApplicantDecidedPathwayCleared vs approvedCleared means the FDA agreed a device resembles one already on sale, while approved means the FDA read the maker's own clinical evidence and accepted it, so the two words describe different amounts of review and are not interchangeable.FDA recordK-numberThe reference the FDA stamps on a 510(k) submission, written like K123456, which is how you pull up the exact record for a device.
Capenergy C Equipments RF C200 and C400 DrakarianCapenergy Medical S.L.10 Jul 2026510(k) · clearedK253480
ChromixTermosalud S.L.1 Jul 2026510(k) · clearedK261473
LED Light Therapy Masks (LED Face Mask Pro FAC08NA…Guangdong Newdermo Biotech Co., Ltd.29 Jun 2026510(k) · clearedK261052
Laser Hair Growth Devices (HR-H1, HR-H2, HR-H3, HR-H4…Ziree Co., Ltd.26 Jun 2026510(k) · clearedK261253
LED Light Therapy Mask (K9C-TK, K9C-K, K9P-YK, K9P-K…Guangdong Newdermo Biotech Co., Ltd.18 Jun 2026510(k) · clearedK260946
Laser Hair Growth Device (F21151, F21152, F21153…Zdeer Technology (Henan) Co., Ltd.16 Jun 2026510(k) · clearedK260899
LED Neck Beauty Mask (ZLD-66A,ZLD-90E,ZLD-130,ZLD-180H)Shenzhen Kaiyan Medical Equipment Co., Ltd.16 Jun 2026510(k) · clearedK254025
Laser Hair Growth System (Laser Cap 128, Laser Helmet…Hubei Yjt Technology Co.,Ltd16 Jun 2026510(k) · clearedK253231
Intense Pulsed Light Therapy DeviceSanhe LEFIS Electronics Co., Ltd.12 Jun 2026510(k) · clearedK261204
Alma TED+ SystemAlma Lasers, Inc.5 Jun 2026510(k) · clearedK251684

A 510(k) clearance means FDA found the device substantially equivalent to one already on sale.

All 231 clearances in the window →

Tile trends: 510(k) clearances per year, 2015–2025; injectables reach market via BLA/PMA, not 510(k).

Most studied

  1. 1
    Topical retinoidAklief, Differin, Renova
    4,253+4%
  2. 2
    Exosome / extracellular-vesicle preparationASCE+
    2,396
  3. 3
    Botulinum toxin (cosmetic)Botox Cosmetic, Daxxify, Dysport
    2,201+25%
  4. 4
    Pulsed dye laserCynergy, Vbeam
    1,530+13%
  5. 5
    Ablative / hybrid fractional laserAcuPulse, Alma Hybrid, CO2RE
    1,485+43%

Counts PubMed records per technique, not per brand — publication volume, not effectiveness.

All 29 techniques →

Picked by a stated rule: most FDA records on file in each category. Filing volume, not quality.

136 devices · 231 clearances · free, no account Browse the index