Dalphene Index

Which aesthetic techniques are being published on more, and less

Updated Jul 26, 2026

Every riser and every faller across all 25 modalities, with the base each percentage was computed from.

Every modality, 2025 vs 2024

18 risers · 5 fallers · 2 flatmethod →

One row per modality: the hollow dot is 2024 papers, the solid dot is 2025, and the connector between them is the change. Rows are ordered by the size of that change in papers, not by percentage.

PubMed papers per modality, 2024 and 2025

papers published in the year

Of the 19 modalities with at least 20 papers, 17 higher, 1 lower and 1 unchanged; the largest single move is Botulinum toxin (cosmetic), up 52 papers.

0100200300Botulinum toxin (cosmetic)2024 206 → 2025 258 ↑+52Poly-L-lactic acid collagen stimulator2024 65 → 2025 109 ↑+44Ablative / hybrid fractional laser2024 94 → 2025 134 ↑+40Hyaluronic acid filler2024 164 → 2025 196 ↑+32Calcium hydroxylapatite filler2024 64 → 2025 94 ↑+30Non-ablative fractional laser2024 82 → 2025 111 ↑+29Mechanical microneedling2024 92 → 2025 119 ↑+27Ultrasound lifting & tightening2024 37 → 2025 64 ↑+27Monopolar RF skin tightening2024 37 → 2025 58 ↑+21IPL / broadband light2024 49 → 2025 65 ↑+16Picosecond laser (pigment & tattoo)2024 38 → 2025 51 ↑+13Pulsed dye laser2024 78 → 2025 88 ↑+10RF body contouring2024 26 → 2025 36 ↑+10Cryolipolysis2024 12 → 2025 21 ↑+9Topical retinoid2024 162 → 2025 169 ↑+7Radiofrequency microneedling2024 44 → 2025 49 ↑+5Topical clascoterone2024 18 → 2025 21 ↑+3Sebaceous-gland laser for acne2024 7 → 2025 8 ↑+1Bimatoprost for eyelash growth2024 7 → 2025 7 →0Topical hydroquinone / triple combination2024 70 → 2025 70 →0Non-invasive laser lipolysis2024 4 → 2025 3 ↓−1High-intensity electromagnetic muscle stimulation2024 8 → 2025 5 ↓−3Laser hair removal2024 50 → 2025 46 ↓−4Hydradermabrasion2024 9 → 2025 2 ↓−7Cellulite septa release2024 10 → 2025 2 ↓−8

One hue at two shades, because both ends are the same quantity for the same modality a year apart. Direction is never colour alone: every row prints its signed change with an arrow. 6 rows drawn at reduced opacity carry fewer than 20 papers, so the spread shown is computed from very few records. The exact count is printed on every row.

PubMed papers per modality in 2024 and 2025, and the change between them
20242025Change
Botulinum toxin (cosmetic)206258+52
Poly-L-lactic acid collagen stimulator65109+44
Ablative / hybrid fractional laser94134+40
Hyaluronic acid filler164196+32
Calcium hydroxylapatite filler6494+30
Non-ablative fractional laser82111+29
Mechanical microneedling92119+27
Ultrasound lifting & tightening3764+27
Monopolar RF skin tightening3758+21
IPL / broadband light4965+16
Picosecond laser (pigment & tattoo)3851+13
Pulsed dye laser7888+10
RF body contouring2636+10
Cryolipolysis1221+9
Topical retinoid162169+7
Radiofrequency microneedling4449+5
Topical clascoterone1821+3
Sebaceous-gland laser for acne78+1
Bimatoprost for eyelash growth770
Topical hydroquinone / triple combination70700
Non-invasive laser lipolysis43−1
High-intensity electromagnetic muscle stimulation85−3
Laser hair removal5046−4
Hydradermabrasion92−7
Cellulite septa release102−8

Two fetched year counts per modality, drawn as they are — no index, no baseline, no fitted trend.

Year-over-year change in PubMed publication volume for all 25 tracked modalities, 2025 vs 2024, with both base counts.

ModalityModalityA family of treatments that work the same way — such as radiofrequency microneedling, or lasers that leave the skin surface intact — rather than any one branded machine.Category2024 papersPubMedThe United States National Library of Medicine's index of published medical literature, which is where this site's paper counts come from.2025 papersChange in papersChange, per cent2016–2026Partial yearA year that has not finished, so its count covers only the part of the year already on record.
Botulinum toxin (cosmetic)Injectables206258+52+25%
Poly-L-lactic acid collagen stimulatorInjectables65109+44+68%
Ablative / hybrid fractional laserLasers & Light94134+40+43%
Hyaluronic acid fillerInjectables164196+32+20%
Calcium hydroxylapatite fillerInjectables6494+30+47%
Non-ablative fractional laserLasers & Light82111+29+35%
Mechanical microneedlingRF & Microneedling92119+27+29%
Ultrasound lifting & tighteningBody Contouring3764+27+73%
Monopolar RF skin tighteningRF & Microneedling3758+21+57%
IPL / broadband lightLasers & Light4965+16+33%
Picosecond laser (pigment & tattoo)Lasers & Light3851+13+34%
Pulsed dye laserLasers & Light7888+10+13%
RF body contouringBody Contouring2636+10+38%
CryolipolysisBody Contouring1221+9+75%
Topical retinoidSkin & Topicals162169+7+4%
Radiofrequency microneedlingRF & Microneedling4449+5+11%
Topical clascoteroneSkin & Topicals1821+3+17%
Sebaceous-gland laser for acneLasers & Light78+1+14%
Bimatoprost for eyelash growthSkin & Topicals7700%
Topical hydroquinone / triple combinationSkin & Topicals707000%
Non-invasive laser lipolysisBody Contouring43-1−25%
High-intensity electromagnetic muscle stimulationBody Contouring85-3−38%
Laser hair removalLasers & Light5046-4−8%
HydradermabrasionSkin & Topicals92-7−78%
Cellulite septa releaseBody Contouring102-8−80%

Ordered by ABSOLUTE change, because a percentage on a base of four is noise, not momentum.

Risers · 2025 vs 2024

18 modalities · one shared scalemethod →

Under every card: papers published in 2025, the last full year, then the change against 2024. Every card shares one vertical scale, so a flat-looking line means a small series, not a stable one.

Botulinum toxin (cosmetic) — PubMed papers per year, 2016–2026 (2026 partial)
Botulinum toxin (cosmetic)
201687
201786
201887
2019105
2020137
2021129
2022140
2023151
2024206
2025258
2026177
258+25%
Poly-L-lactic acid collagen stimulator — PubMed papers per year, 2016–2026 (2026 partial)
Poly-L-lactic acid collagen stimulator
201613
201718
201815
201915
202032
202132
202227
202335
202465
2025109
202676
109+68%
Ablative / hybrid fractional laser — PubMed papers per year, 2016–2026 (2026 partial)
Ablative / hybrid fractional laser
2016100
201782
201880
2019100
2020118
2021141
2022111
202384
202494
2025134
202683
134+43%
Hyaluronic acid filler — PubMed papers per year, 2016–2026 (2026 partial)
Hyaluronic acid filler
201644
201755
201864
201980
2020110
2021119
2022114
2023128
2024164
2025196
2026120
196+20%
Calcium hydroxylapatite filler — PubMed papers per year, 2016–2026 (2026 partial)
Calcium hydroxylapatite filler
201620
201723
201834
201919
202035
202129
202239
202345
202464
202594
202658
94+47%
Non-ablative fractional laser — PubMed papers per year, 2016–2026 (2026 partial)
Non-ablative fractional laser
201690
201773
201882
201978
202090
202183
202293
202366
202482
2025111
202654
111+35%
Mechanical microneedling — PubMed papers per year, 2016–2026 (2026 partial)
Mechanical microneedling
201617
201725
201829
201947
202057
202161
202269
202374
202492
2025119
202675
119+29%
Ultrasound lifting & tightening — PubMed papers per year, 2016–2026 (2026 partial)
Ultrasound lifting & tightening
201620
201720
201819
201924
202027
202118
202219
202331
202437
202564
202625
64+73%
Monopolar RF skin tightening — PubMed papers per year, 2016–2026 (2026 partial)
Monopolar RF skin tightening
201625
201719
201818
201920
202027
202131
202237
202326
202437
202558
202636
58+57%
IPL / broadband light — PubMed papers per year, 2016–2026 (2026 partial)
IPL / broadband light
201650
201739
201842
201951
202048
202149
202250
202359
202449
202565
202657
65+33%
Picosecond laser (pigment & tattoo) — PubMed papers per year, 2016–2026 (2026 partial)
Picosecond laser (pigment & tattoo)
20169
201717
201826
201927
202042
202151
202235
202338
202438
202551
202631
51+34%
Pulsed dye laser — PubMed papers per year, 2016–2026 (2026 partial)
Pulsed dye laser
201655
201763
201867
201954
202061
202183
202268
202362
202478
202588
202646
88+13%
RF body contouring — PubMed papers per year, 2016–2026 (2026 partial)
RF body contouring
201617
201715
20188
201913
202014
202115
202224
202327
202426
202536
20268
36+38%
Cryolipolysis — PubMed papers per year, 2016–2026 (2026 partial)
Cryolipolysis
201625
201719
201826
201912
202026
202123
202228
202332
202412
202521
20266
21+75%
Topical retinoid — PubMed papers per year, 2016–2026 (2026 partial)
Topical retinoid
2016121
2017121
2018110
2019127
2020141
2021155
2022138
2023150
2024162
2025169
2026110
169+4%
Radiofrequency microneedling — PubMed papers per year, 2016–2026 (2026 partial)
Radiofrequency microneedling
201619
201711
201820
201925
202031
202142
202248
202329
202444
202549
202638
49+11%
Topical clascoterone — PubMed papers per year, 2016–2026 (2026 partial)
Topical clascoterone
20160
20171
20181
20195
20206
202112
20226
202312
202418
202521
202614
21+17%
Sebaceous-gland laser for acne — PubMed papers per year, 2016–2026 (2026 partial)
Sebaceous-gland laser for acne
20162
20173
20180
20194
20202
20211
20225
20237
20247
20258
202610
8+14%

Every card shares ONE y-axis, so a flat-looking line means a small series, not a stable one.

Fallers · 2025 vs 2024

5 modalities · one shared scalemethod →

Under every card: papers published in 2025, the last full year, then the change against 2024. Every card shares one vertical scale, so a flat-looking line means a small series, not a stable one.

Non-invasive laser lipolysis — PubMed papers per year, 2016–2026 (2026 partial)
Non-invasive laser lipolysis
20168
20176
20188
20192
20204
202110
20227
20235
20244
20253
20261
3−25%
High-intensity electromagnetic muscle stimulation — PubMed papers per year, 2016–2026 (2026 partial)
High-intensity electromagnetic muscle stimulation
20160
20170
20184
20196
20208
202114
20229
202314
20248
20255
20264
5−38%
Laser hair removal — PubMed papers per year, 2016–2026 (2026 partial)
Laser hair removal
201631
201730
201837
201929
202042
202139
202242
202344
202450
202546
202630
46−8%
Hydradermabrasion — PubMed papers per year, 2016–2026 (2026 partial)
Hydradermabrasion
20166
20179
20189
201912
20207
20218
20226
20239
20249
20252
20265
2−78%
Cellulite septa release — PubMed papers per year, 2016–2026 (2026 partial)
Cellulite septa release
20162
20173
20185
20196
20202
20214
20224
202313
202410
20252
20263
2−80%

Every card shares ONE y-axis, so a flat-looking line means a small series, not a stable one.

Neither a riser nor a faller

2 modalities

Flat and unknown are kept visible, not dropped — a missing series is not a zero.