Dalphene Index

Most-studied aesthetic treatments, by published research

Updated Jul 26, 2026

Every published-literature series behind the rankings hero, including all 25 modality queries one by one.

Research attention, 2016–2026

method →
1,786papers · 2025

papers per year · 2016–2026 · 2026 partial

Papers a year rose 120% between 2016 and 2025, from 813 to 1,786; Injectables added the most (up 493 papers) and Body Contouring the least (up 59).

05001,0001,5002,000InjectablesLasers & Light201620182020202220242026

Values and shares are 2025, the latest full year.

PubMed papers per year by category, 2016–2026 (2026 partial)
Lasers & LightInjectablesBody ContouringSkin & TopicalsRF & MicroneedlingTotal
20163371647217961813
20173071826317355780
20183342007015467825
20193432196319392910
2020403314812111151,124
2021447309842391341,213
2022404320912271541,196
20233603591222321291,202
2024398499972661731,433
20255036571312692261,786
2026311431471901491,128

PubMed records per year matching our fixed treatment queries — publication volume, not quality, efficacy or market share.

Every modality series

25 modalities · sortablemethod →

All 25 tracked modalities: PubMed publication counts, the two latest full years, the year-over-year change and the source query for each.

ModalityModalityA family of treatments that work the same way — such as radiofrequency microneedling, or lasers that leave the skin surface intact — rather than any one branded machine.CategoryPapers, last 10 yearsAll time20252024Change2016–2026Source
Botulinum toxin (cosmetic)Injectables1,3622,201258206+25%query
Topical retinoidSkin & Topicals1,3324,253169162+4%query
Hyaluronic acid fillerInjectables1,0331,298196164+20%query
Ablative / hybrid fractional laserLasers & Light9401,48513494+43%query
Non-ablative fractional laserLasers & Light7421,15711182+35%query
Pulsed dye laserLasers & Light6131,5308878+13%query
Mechanical microneedlingRF & Microneedling56461911992+29%query
Topical hydroquinone / triple combinationSkin & Topicals5091,11670700%query
IPL / broadband lightLasers & Light4881,0286549+33%query
Calcium hydroxylapatite fillerInjectables4085829464+47%query
Poly-L-lactic acid collagen stimulatorInjectables37158610965+68%query
Laser hair removalLasers & Light3597444650−8%query
Picosecond laser (pigment & tattoo)Lasers & Light3063235138+34%query
Radiofrequency microneedlingRF & Microneedling3043544944+11%query
Monopolar RF skin tighteningRF & Microneedling2934325837+57%query
Ultrasound lifting & tighteningBody Contouring2613176437+73%query
CryolipolysisBody Contouring1992452112+75%query
RF body contouringBody Contouring1742553626+38%query
Topical clascoteroneSkin & Topicals88902118+17%query
HydradermabrasionSkin & Topicals7316629−78%query
High-intensity electromagnetic muscle stimulationBody Contouring616158−38%query
Bimatoprost for eyelash growthSkin & Topicals52128770%query
Non-invasive laser lipolysisBody Contouring4911234−25%query
Cellulite septa releaseBody Contouring4550210−80%query
Sebaceous-gland laser for acneLasers & Light406687+14%query

Publication volume for a TREATMENT, not a brand — every brand on a modality shares its number.

All 25 series, side by side

shared or own scalemethod →

Under every card, left to right: papers published in 2025, the last full year, and that series' own highest single year. The final point of each line is the partial current year and is drawn hollow.

Botulinum toxin (cosmetic) — PubMed papers per year, 2016–2026 (2026 partial)
Botulinum toxin (cosmetic)
201687
201786
201887
2019105
2020137
2021129
2022140
2023151
2024206
2025258
2026177
258258
Topical retinoid — PubMed papers per year, 2016–2026 (2026 partial)
Topical retinoid
2016121
2017121
2018110
2019127
2020141
2021155
2022138
2023150
2024162
2025169
2026110
169169
Hyaluronic acid filler — PubMed papers per year, 2016–2026 (2026 partial)
Hyaluronic acid filler
201644
201755
201864
201980
2020110
2021119
2022114
2023128
2024164
2025196
2026120
196196
Ablative / hybrid fractional laser — PubMed papers per year, 2016–2026 (2026 partial)
Ablative / hybrid fractional laser
2016100
201782
201880
2019100
2020118
2021141
2022111
202384
202494
2025134
202683
134141
Non-ablative fractional laser — PubMed papers per year, 2016–2026 (2026 partial)
Non-ablative fractional laser
201690
201773
201882
201978
202090
202183
202293
202366
202482
2025111
202654
111111
Pulsed dye laser — PubMed papers per year, 2016–2026 (2026 partial)
Pulsed dye laser
201655
201763
201867
201954
202061
202183
202268
202362
202478
202588
202646
8888
Mechanical microneedling — PubMed papers per year, 2016–2026 (2026 partial)
Mechanical microneedling
201617
201725
201829
201947
202057
202161
202269
202374
202492
2025119
202675
119119
Topical hydroquinone / triple combination — PubMed papers per year, 2016–2026 (2026 partial)
Topical hydroquinone / triple combination
201646
201736
201829
201944
202051
202160
202269
202356
202470
202570
202658
7070
IPL / broadband light — PubMed papers per year, 2016–2026 (2026 partial)
IPL / broadband light
201650
201739
201842
201951
202048
202149
202250
202359
202449
202565
202657
6565
Calcium hydroxylapatite filler — PubMed papers per year, 2016–2026 (2026 partial)
Calcium hydroxylapatite filler
201620
201723
201834
201919
202035
202129
202239
202345
202464
202594
202658
9494
Poly-L-lactic acid collagen stimulator — PubMed papers per year, 2016–2026 (2026 partial)
Poly-L-lactic acid collagen stimulator
201613
201718
201815
201915
202032
202132
202227
202335
202465
2025109
202676
109109
Laser hair removal — PubMed papers per year, 2016–2026 (2026 partial)
Laser hair removal
201631
201730
201837
201929
202042
202139
202242
202344
202450
202546
202630
4650
Picosecond laser (pigment & tattoo) — PubMed papers per year, 2016–2026 (2026 partial)
Picosecond laser (pigment & tattoo)
20169
201717
201826
201927
202042
202151
202235
202338
202438
202551
202631
5151
Radiofrequency microneedling — PubMed papers per year, 2016–2026 (2026 partial)
Radiofrequency microneedling
201619
201711
201820
201925
202031
202142
202248
202329
202444
202549
202638
4949
Monopolar RF skin tightening — PubMed papers per year, 2016–2026 (2026 partial)
Monopolar RF skin tightening
201625
201719
201818
201920
202027
202131
202237
202326
202437
202558
202636
5858
Ultrasound lifting & tightening — PubMed papers per year, 2016–2026 (2026 partial)
Ultrasound lifting & tightening
201620
201720
201819
201924
202027
202118
202219
202331
202437
202564
202625
6464
Cryolipolysis — PubMed papers per year, 2016–2026 (2026 partial)
Cryolipolysis
201625
201719
201826
201912
202026
202123
202228
202332
202412
202521
20266
2132
RF body contouring — PubMed papers per year, 2016–2026 (2026 partial)
RF body contouring
201617
201715
20188
201913
202014
202115
202224
202327
202426
202536
20268
3636
Topical clascoterone — PubMed papers per year, 2016–2026 (2026 partial)
Topical clascoterone
20160
20171
20181
20195
20206
202112
20226
202312
202418
202521
202614
2121
Hydradermabrasion — PubMed papers per year, 2016–2026 (2026 partial)
Hydradermabrasion
20166
20179
20189
201912
20207
20218
20226
20239
20249
20252
20265
212
High-intensity electromagnetic muscle stimulation — PubMed papers per year, 2016–2026 (2026 partial)
High-intensity electromagnetic muscle stimulation
20160
20170
20184
20196
20208
202114
20229
202314
20248
20255
20264
514
Bimatoprost for eyelash growth — PubMed papers per year, 2016–2026 (2026 partial)
Bimatoprost for eyelash growth
20166
20176
20185
20195
20206
20214
20228
20235
20247
20257
20263
78
Non-invasive laser lipolysis — PubMed papers per year, 2016–2026 (2026 partial)
Non-invasive laser lipolysis
20168
20176
20188
20192
20204
202110
20227
20235
20244
20253
20261
310
Cellulite septa release — PubMed papers per year, 2016–2026 (2026 partial)
Cellulite septa release
20162
20173
20185
20196
20202
20214
20224
202313
202410
20252
20263
213
Sebaceous-gland laser for acne — PubMed papers per year, 2016–2026 (2026 partial)
Sebaceous-gland laser for acne
20162
20173
20180
20194
20202
20211
20225
20237
20247
20258
202610
810

Two honest views of the same 25 series: comparable heights, or readable shapes. Neither is the truth on its own.