Devices linked to wrinkles & lines

Derived area

75 products · matched by keyword rule, not the cleared indication

Filters

75 products

AcuPulse

Lumenis, Ltd. · Lasers & Light

510(k) · clearedClass IIK212703EU

Cleared2008Studies1,485Trials229

AestheFill

Maker — · Injectables

No US authorization

Decision—Studies450Trials49

Agnes RF

Agnes Medical Co., Ltd. · RF & Microneedling

510(k) · clearedClass IIK250217

Cleared2017Studies354Trials37

Aklief

GALDERMA LABS LP · Skin & Topicals

NDA · approvedNDA211527

Approved2019Studies4,253Trials343

Alma Hybrid

Alma Lasers, Inc. · Lasers & Light

510(k) · clearedClass IIK251230EU

Cleared2021Studies1,485Trials229

ASCE+

Maker — · Injectables

No US authorization

Decision—Studies2,396Trials79

Belotero Balance

Merz North America, Inc. · Injectables

PMA · approvedP090016

Approved2011Studies1,298Trials46

Belotero Intense (+) Lidocaine

Merz North America, Inc. · Injectables

PMA · approvedP250016

Approved2026Studies1,298Trials46

Belotero Volume (+) Lidocaine

Merz North America, Inc. · Injectables

PMA · approvedP250020

Approved2026Studies1,298Trials46

Botox Cosmetic

ALLERGAN · Injectables

BLA · approvedBLA103000

Approved1991Studies2,201Trials186

CellREDM

Maker — · Injectables

No US authorization

Decision—Studies158Trials106

Clear + Brilliant

Solta Medical, Inc. · Lasers & Light

510(k) · clearedClass IIK223647EU

Cleared2011Studies1,157Trials128

CO2RE

Syneron-Candela Corp · Lasers & Light

510(k) · clearedClass IIK181523

Cleared2015Studies1,485Trials229

Daxxify

REVANCE THERAPEUTICS, INC. · Injectables

BLA · approvedBLA761127

Approved2022Studies2,201Trials186

Differin

GALDERMA LABS LP · Skin & Topicals

NDA · approvedNDA020380

Approved1996Studies4,253Trials343

Dysport

IPSEN BIOPHARM LTD · Injectables

BLA · approvedBLA125274

Approved2009Studies2,201Trials186

eCO2

Lutronic Corporation · Lasers & Light

510(k) · clearedClass IIK244060

Cleared2008Studies1,485Trials229

ellacor

Cytrellis Biosystems, Inc. · RF & Microneedling

510(k) · clearedClass IIK252752

Cleared2025Studies619Trials135

Elravie Re2O

Maker — · Injectables

No US authorization

Decision—Studies158Trials106

EndyMed Intensif

Endymed Medical, Ltd. · RF & Microneedling

510(k) · clearedClass IIK130501

Cleared2014Studies354Trials37

Fractora

Invasix , Ltd. · RF & Microneedling

510(k) · clearedClass IIK102461

Cleared2011Studies354Trials37

Frax

Candela Corporation · Lasers & Light

510(k) · clearedClass IIK212492EU

Cleared2016Studies1,157Trials128

Fraxel

Solta Medical · Lasers & Light

510(k) · clearedClass IIK242142EU

Cleared2005Studies1,157Trials128

Genius

Cynosure Lutronic Technology Corporation · RF & Microneedling

510(k) · clearedClass IIK253484EU

Cleared2018Studies354Trials37

Halo

Maker — · Lasers & Light

Unverified mapping

Decision—Studies1,485Trials229

Infini

Lutronic Corporation · RF & Microneedling

510(k) · clearedClass IIK121481

Cleared2013Studies354Trials37

INTRAcel

Jeisys Medical, Inc. · RF & Microneedling

510(k) · clearedClass IIK183284

Cleared2016Studies354Trials37

Jeuveau

EVOLUS INC · Injectables

BLA · approvedBLA761085

Approved2019Studies2,201Trials186

Juveacell

Maker — · Injectables

No US authorization

Decision—Studies158Trials106

Juvederm Ultra XC

Allergan · Injectables

PMA · approvedP050047

Approved2010Studies1,298Trials46

Juvederm Volbella XC

Allergan · Injectables

PMA · approvedP110033

Approved2016Studies1,298Trials46

Juvederm Vollure XC

Allergan · Injectables

PMA · approvedP110033

Approved2017Studies1,298Trials46

Juvederm Voluma XC

Allergan · Injectables

PMA · approvedP110033

Approved2013Studies1,298Trials46

Juvederm Volux XC

Allergan · Injectables

PMA · approvedP110033

Approved2022Studies1,298Trials46

LaseMD

Lutronic Global · Lasers & Light

510(k) · clearedClass IIK192331EU

Cleared2017Studies1,157Trials128

Letybo

HUGEL INC · Injectables

BLA · approvedBLA761225

Approved2024Studies2,201Trials186

LightStim

Led Intellectual Properties, LLC · Lasers & Light

510(k) · clearedClass IIK212771EU

Cleared2010Studies—Trials—

MicroPen EVO

Eclipse Medcorp, LLC · RF & Microneedling

510(k) · clearedClass IIK212558

Cleared2021Studies619Trials135

Morpheus8

InMode , Ltd. · RF & Microneedling

510(k) · clearedClass IIK240017EU

Cleared2019Studies354Trials37

Omnilux

Globalmed Technologies · Lasers & Light

510(k) · clearedClass IIK210948

Cleared2003Studies—Trials—

Potenza

Jeisys Medical, Inc. · RF & Microneedling

510(k) · clearedClass IIK231216EU

Cleared2020Studies354Trials37

Profhilo

Maker — · Injectables

No US authorization

Decision—Studies1,298Trials46

Profound

Candela Corporation · RF & Microneedling

510(k) · clearedClass IIK240070

Cleared2016Studies354Trials37

Radiesse

Merz North America, Inc. · Injectables

PMA · approvedP050037

Approved2006Studies582Trials7

Rejuran

Maker — · Injectables

No US authorization

Decision—Studies155Trials16

Rejuvapen NXT

Refine USA, LLC · RF & Microneedling

510(k) · clearedClass IIK192138

Cleared2020Studies619Trials135

Renova

VALEANT PHARMS NORTH · Skin & Topicals

NDA · approvedNDA021108

Approved2000Studies4,253Trials343

Restylane Defyne

Q-Med AB · Injectables

PMA · approvedP140029EU

Approved2016Studies1,298Trials46

Restylane Kysse

Q-Med AB · Injectables

PMA · approvedP140029EU

Approved2020Studies1,298Trials46

Restylane Lyft

Q-Med AB · Injectables

PMA · approvedP040024EU

Approved2015Studies1,298Trials46

Restylane Silk

Q-Med AB · Injectables

PMA · approvedP040024

Approved2014Studies1,298Trials46

Retin-A

BAUSCH · Skin & Topicals

NDA · approvedNDA017340

Approved1973Studies4,253Trials343

Revanesse Versa

Prollenium Medical Technologies, Inc. · Injectables

PMA · approvedP160042

Approved2017Studies1,298Trials46

RHA Collection

Teoxane S.A. · Injectables

PMA · approvedP170002

Approved2017Studies1,298Trials46

Scarlet SRF

VIOL Co., Ltd. · RF & Microneedling

510(k) · clearedClass IIK180872

Cleared2018Studies354Trials37

Sculptra

Q-Med AB · Injectables

PMA · approvedP030050EU

Approved2004Studies586Trials17

Secret Pro

Ilooda Co,., Ltd. · RF & Microneedling

510(k) · clearedClass IIK233374

Cleared2023Studies354Trials37

Secret RF

Ilooda Co,., Ltd. · RF & Microneedling

510(k) · clearedClass IIK182355

Cleared2017Studies354Trials37

SkinPen

Crown Aesthetics · RF & Microneedling

510(k) · clearedClass IIK241400EU

Cleared2018Studies619Trials135

SkinStylus

Esthetic Medical, Inc. · RF & Microneedling

510(k) · clearedClass IIK253002

Cleared2020Studies619Trials135

SKINVIVE by Juvederm

Allergan · Injectables

PMA · approvedP110033

Approved2023Studies1,298Trials46

SmartXide

El.En S.P.A. · Lasers & Light

510(k) · clearedClass IIK240537EU

Cleared2003Studies1,485Trials229

Sofwave

Sofwave Medical, Ltd. · Body Contouring

510(k) · clearedClass IIK250146EU

Cleared2021Studies317Trials16

SP Dynamis

Fotona D.O.O. · Lasers & Light

510(k) · clearedClass IIK213267

Cleared2011Studies1,485Trials229

Sylfirm X

VIOL Co., Ltd. · RF & Microneedling

510(k) · clearedClass IIK213612EU

Cleared2020Studies354Trials37

Tazorac

ALMIRALL · Skin & Topicals

NDA · approvedNDA020600

Approved1997Studies4,253Trials343

TempSure

Cynosure, LLC · RF & Microneedling

510(k) · clearedClass IIK223292EU

Cleared2017Studies432Trials9

Thermage

Solta Medical · RF & Microneedling

510(k) · clearedClass IIK173759EU

Cleared2000Studies432Trials9

Ultherapy

Ulthera, Inc. · Body Contouring

510(k) · clearedClass IIK260618

Cleared2009Studies317Trials16

UltraPulse

Lumenis Be, Ltd. · Lasers & Light

510(k) · clearedClass IIK233301EU

Cleared1991Studies1,485Trials229

Venus Viva

Venus Concept USA, Inc. · RF & Microneedling

510(k) · clearedClass IIK201164

Cleared2015Studies354Trials37

VirtueRF

ShenB Co., Ltd. · RF & Microneedling

510(k) · clearedClass IIK211562

Cleared2021Studies354Trials37

Vivace

ShenB Co., Ltd. · RF & Microneedling

510(k) · clearedClass IIK193070EU

Cleared2016Studies354Trials37

Volnewmer

Classys, Inc. · RF & Microneedling

510(k) · clearedClass IIK240248EU

Cleared2024Studies432Trials9

Xeomin

MERZ PHARMS · Injectables

BLA · approvedBLA125360

Approved2010Studies2,201Trials186

Copied from public FDA, PubMed and ClinicalTrials.gov records; unknown values show an em-dash.
Product	Manufacturer	Category	Pathway	Class	First decision	Studies	Trials
AcuPulse EU	Lumenis, Ltd.	Lasers & Light	510(k) — cleared	Class II	Dec 18 2008	1,485	229
AestheFill	—	Injectables	No US authorization found	—	—	450	49
Agnes RF	Agnes Medical Co., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Jan 5 2017	354	37
Aklief	GALDERMA LABS LP	Skin & Topicals	NDA — approved	—	Oct 4 2019	4,253	343
Alma Hybrid EU	Alma Lasers, Inc.	Lasers & Light	510(k) — cleared	Class II	Jul 2 2021	1,485	229
ASCE+	—	Injectables	No US authorization found	—	—	2,396	79
Belotero Balance	Merz North America, Inc.	Injectables	PMA — approved	—	Nov 14 2011	1,298	46
Belotero Intense (+) Lidocaine	Merz North America, Inc.	Injectables	PMA — approved	—	Jul 9 2026	1,298	46
Belotero Volume (+) Lidocaine	Merz North America, Inc.	Injectables	PMA — approved	—	May 19 2026	1,298	46
Botox Cosmetic	ALLERGAN	Injectables	BLA — approved	—	Dec 9 1991	2,201	186
CellREDM	—	Injectables	No US authorization found	—	—	158	106
Clear + Brilliant EU	Solta Medical, Inc.	Lasers & Light	510(k) — cleared	Class II	May 3 2011	1,157	128
CO2RE	Syneron-Candela Corp	Lasers & Light	510(k) — cleared	Class II	Sep 15 2015	1,485	229
Daxxify	REVANCE THERAPEUTICS, INC.	Injectables	BLA — approved	—	Sep 7 2022	2,201	186
Differin	GALDERMA LABS LP	Skin & Topicals	NDA — approved	—	May 31 1996	4,253	343
Dysport	IPSEN BIOPHARM LTD	Injectables	BLA — approved	—	Apr 29 2009	2,201	186
eCO2	Lutronic Corporation	Lasers & Light	510(k) — cleared	Class II	Jul 7 2008	1,485	229
ellacor	Cytrellis Biosystems, Inc.	RF & Microneedling	510(k) — cleared	Class II	Oct 30 2025	619	135
Elravie Re2O	—	Injectables	No US authorization found	—	—	158	106
EndyMed Intensif	Endymed Medical, Ltd.	RF & Microneedling	510(k) — cleared	Class II	Mar 13 2014	354	37
Fractora	Invasix , Ltd.	RF & Microneedling	510(k) — cleared	Class II	Jun 2 2011	354	37
Frax EU	Candela Corporation	Lasers & Light	510(k) — cleared	Class II	Sep 16 2016	1,157	128
Fraxel EU	Solta Medical	Lasers & Light	510(k) — cleared	Class II	Jul 5 2005	1,157	128
Genius EU	Cynosure Lutronic Technology Corporation	RF & Microneedling	510(k) — cleared	Class II	Dec 10 2018	354	37
Halo	—	Lasers & Light	Not verified	—	—	1,485	229
Infini	Lutronic Corporation	RF & Microneedling	510(k) — cleared	Class II	Jun 25 2013	354	37
INTRAcel	Jeisys Medical, Inc.	RF & Microneedling	510(k) — cleared	Class II	Jul 21 2016	354	37
Jeuveau	EVOLUS INC	Injectables	BLA — approved	—	Feb 1 2019	2,201	186
Juveacell	—	Injectables	No US authorization found	—	—	158	106
Juvederm Ultra XC	Allergan	Injectables	PMA — approved	—	Jan 7 2010	1,298	46
Juvederm Volbella XC	Allergan	Injectables	PMA — approved	—	May 31 2016	1,298	46
Juvederm Vollure XC	Allergan	Injectables	PMA — approved	—	Mar 17 2017	1,298	46
Juvederm Voluma XC	Allergan	Injectables	PMA — approved	—	Oct 22 2013	1,298	46
Juvederm Volux XC	Allergan	Injectables	PMA — approved	—	Jul 29 2022	1,298	46
LaseMD EU	Lutronic Global	Lasers & Light	510(k) — cleared	Class II	Jun 23 2017	1,157	128
Letybo	HUGEL INC	Injectables	BLA — approved	—	Feb 29 2024	2,201	186
LightStim EU	Led Intellectual Properties, LLC	Lasers & Light	510(k) — cleared	Class II	Jul 1 2010	—	—
MicroPen EVO	Eclipse Medcorp, LLC	RF & Microneedling	510(k) — cleared	Class II	May 25 2021	619	135
Morpheus8 EU	InMode , Ltd.	RF & Microneedling	510(k) — cleared	Class II	Dec 27 2019	354	37
Omnilux	Globalmed Technologies	Lasers & Light	510(k) — cleared	Class II	Jun 18 2003	—	—
Potenza EU	Jeisys Medical, Inc.	RF & Microneedling	510(k) — cleared	Class II	Feb 20 2020	354	37
Profhilo	—	Injectables	No US authorization found	—	—	1,298	46
Profound	Candela Corporation	RF & Microneedling	510(k) — cleared	Class II	Sep 12 2016	354	37
Radiesse	Merz North America, Inc.	Injectables	PMA — approved	—	Dec 22 2006	582	7
Rejuran	—	Injectables	No US authorization found	—	—	155	16
Rejuvapen NXT	Refine USA, LLC	RF & Microneedling	510(k) — cleared	Class II	Apr 9 2020	619	135
Renova	VALEANT PHARMS NORTH	Skin & Topicals	NDA — approved	—	Aug 31 2000	4,253	343
Restylane Defyne EU	Q-Med AB	Injectables	PMA — approved	—	Dec 9 2016	1,298	46
Restylane Kysse EU	Q-Med AB	Injectables	PMA — approved	—	Mar 26 2020	1,298	46
Restylane Lyft EU	Q-Med AB	Injectables	PMA — approved	—	Aug 31 2015	1,298	46
Restylane Silk	Q-Med AB	Injectables	PMA — approved	—	Jun 13 2014	1,298	46
Retin-A	BAUSCH	Skin & Topicals	NDA — approved	—	Jan 26 1973	4,253	343
Revanesse Versa	Prollenium Medical Technologies, Inc.	Injectables	PMA — approved	—	Oct 2 2017	1,298	46
RHA Collection	Teoxane S.A.	Injectables	PMA — approved	—	Oct 19 2017	1,298	46
Scarlet SRF	VIOL Co., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Oct 11 2018	354	37
Sculptra EU	Q-Med AB	Injectables	PMA — approved	—	Aug 3 2004	586	17
Secret Pro	Ilooda Co,., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Dec 14 2023	354	37
Secret RF	Ilooda Co,., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Jun 13 2017	354	37
SkinPen EU	Crown Aesthetics	RF & Microneedling	510(k) — cleared	Class II	Mar 1 2018	619	135
SkinStylus	Esthetic Medical, Inc.	RF & Microneedling	510(k) — cleared	Class II	Apr 10 2020	619	135
SKINVIVE by Juvederm	Allergan	Injectables	PMA — approved	—	May 11 2023	1,298	46
SmartXide EU	El.En S.P.A.	Lasers & Light	510(k) — cleared	Class II	May 9 2003	1,485	229
Sofwave EU	Sofwave Medical, Ltd.	Body Contouring	510(k) — cleared	Class II	Nov 15 2021	317	16
SP Dynamis	Fotona D.O.O.	Lasers & Light	510(k) — cleared	Class II	Jul 1 2011	1,485	229
Sylfirm X EU	VIOL Co., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Apr 22 2020	354	37
Tazorac	ALMIRALL	Skin & Topicals	NDA — approved	—	Jun 13 1997	4,253	343
TempSure EU	Cynosure, LLC	RF & Microneedling	510(k) — cleared	Class II	Sep 22 2017	432	9
Thermage EU	Solta Medical	RF & Microneedling	510(k) — cleared	Class II	Jul 19 2000	432	9
Ultherapy	Ulthera, Inc.	Body Contouring	510(k) — cleared	Class II	Sep 11 2009	317	16
UltraPulse EU	Lumenis Be, Ltd.	Lasers & Light	510(k) — cleared	Class II	Aug 13 1991	1,485	229
Venus Viva	Venus Concept USA, Inc.	RF & Microneedling	510(k) — cleared	Class II	May 12 2015	354	37
VirtueRF	ShenB Co., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Jan 22 2021	354	37
Vivace EU	ShenB Co., Ltd.	RF & Microneedling	510(k) — cleared	Class II	Jan 15 2016	354	37
Volnewmer EU	Classys, Inc.	RF & Microneedling	510(k) — cleared	Class II	Apr 29 2024	432	9
Xeomin	MERZ PHARMS	Injectables	BLA — approved	—	Jul 30 2010	2,201	186

Curated seed list; study and trial counts are per modality, not per brand.

Sorted by most recent FDA decision — a filing date, not a quality signal.

How each product matched (75)

Product	Matched term	Source string
AcuPulse	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
AestheFill	wrinkle	ClinicalTrials.gov condition query for PDLLA / PLLA collagen biostimulator
Agnes RF	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Aklief	wrinkle	ClinicalTrials.gov condition query for Topical retinoid
Alma Hybrid	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
ASCE+	wrinkle	ClinicalTrials.gov condition query for Exosome / extracellular-vesicle preparation
Belotero Balance	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Belotero Intense (+) Lidocaine	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Belotero Volume (+) Lidocaine	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Botox Cosmetic	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)
CellREDM	wrinkle	ClinicalTrials.gov condition query for Human acellular dermal matrix (ECM) booster
Clear + Brilliant	wrinkle	ClinicalTrials.gov condition query for Non-ablative fractional laser
CO2RE	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
Daxxify	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)
Differin	wrinkle	ClinicalTrials.gov condition query for Topical retinoid
Dysport	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)
eCO2	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
ellacor	wrinkle	ClinicalTrials.gov condition query for Mechanical microneedling
Elravie Re2O	wrinkle	ClinicalTrials.gov condition query for Human acellular dermal matrix (ECM) booster
EndyMed Intensif	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Fractora	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Frax	wrinkle	ClinicalTrials.gov condition query for Non-ablative fractional laser
Fraxel	wrinkle	ClinicalTrials.gov condition query for Non-ablative fractional laser
Genius	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Halo	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
Infini	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
INTRAcel	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Jeuveau	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)
Juveacell	wrinkle	ClinicalTrials.gov condition query for Human acellular dermal matrix (ECM) booster
Juvederm Ultra XC	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Juvederm Volbella XC	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Juvederm Vollure XC	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Juvederm Voluma XC	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Juvederm Volux XC	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
LaseMD	wrinkle	ClinicalTrials.gov condition query for Non-ablative fractional laser
Letybo	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)
LightStim	wrinkle	FDA product code OHS — Light Based Over The Counter Wrinkle Reduction
MicroPen EVO	wrinkle	ClinicalTrials.gov condition query for Mechanical microneedling
Morpheus8	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Omnilux	wrinkle	FDA product code OHS — Light Based Over The Counter Wrinkle Reduction
Potenza	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Profhilo	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Profound	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Radiesse	wrinkle	ClinicalTrials.gov condition query for Calcium hydroxylapatite filler
Rejuran	wrinkle	ClinicalTrials.gov condition query for Polynucleotide (PDRN) skin booster
Rejuvapen NXT	wrinkle	ClinicalTrials.gov condition query for Mechanical microneedling
Renova	wrinkle	ClinicalTrials.gov condition query for Topical retinoid
Restylane Defyne	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Restylane Kysse	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Restylane Lyft	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Restylane Silk	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Retin-A	wrinkle	ClinicalTrials.gov condition query for Topical retinoid
Revanesse Versa	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
RHA Collection	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
Scarlet SRF	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Sculptra	wrinkle	ClinicalTrials.gov condition query for Poly-L-lactic acid collagen stimulator
Secret Pro	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Secret RF	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
SkinPen	wrinkle	ClinicalTrials.gov condition query for Mechanical microneedling
SkinStylus	wrinkle	ClinicalTrials.gov condition query for Mechanical microneedling
SKINVIVE by Juvederm	wrinkle	ClinicalTrials.gov condition query for Hyaluronic acid filler
SmartXide	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
Sofwave	wrinkle	ClinicalTrials.gov condition query for Ultrasound lifting & tightening
SP Dynamis	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
Sylfirm X	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Tazorac	wrinkle	ClinicalTrials.gov condition query for Topical retinoid
TempSure	wrinkle	ClinicalTrials.gov condition query for Monopolar RF skin tightening
Thermage	wrinkle	ClinicalTrials.gov condition query for Monopolar RF skin tightening
Ultherapy	wrinkle	ClinicalTrials.gov condition query for Ultrasound lifting & tightening
UltraPulse	wrinkle	ClinicalTrials.gov condition query for Ablative / hybrid fractional laser
Venus Viva	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
VirtueRF	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Vivace	wrinkle	ClinicalTrials.gov condition query for Radiofrequency microneedling
Volnewmer	wrinkle	ClinicalTrials.gov condition query for Monopolar RF skin tightening
Xeomin	wrinkle	ClinicalTrials.gov condition query for Botulinum toxin (cosmetic)

Derived by keyword rule from real source strings, not the cleared indication.

Devices linked to wrinkles & lines

Category

FDA pathway510(k) = cleared

Manufacturer47

Treatment areaderived

Evidenceper modality

EU registerpresence only

Devices linked to wrinkles & lines

Category

FDA pathwayCleared vs approvedCleared means the FDA agreed a device resembles one already on sale, while approved means the FDA read the maker's own clinical evidence and accepted it, so the two words describe different amounts of review and are not interchangeable.510(k) = cleared

Manufacturer47

Treatment areaderived

Evidenceper modality

EU registerpresence only

FDA pathway510(k) = cleared