GALDERMA LABS LP · Skin & Topicals
NDA · approvedNDA211527
Approved2019Studies4,253Trials343
Devices linked to pigment & melasma
26 products · matched by keyword rule, not the cleared indication
26 products
Sciton, Inc · Lasers & Light
510(k) · clearedClass IIK032460
Cleared2003Studies1,028Trials43
Solta Medical, Inc. · Lasers & Light
510(k) · clearedClass IIK223647EU
Cleared2011Studies1,157Trials128
GALDERMA LABS LP · Skin & Topicals
NDA · approvedNDA020380
Approved1996Studies4,253Trials343
Quanta System Spa · Lasers & Light
510(k) · clearedClass IIK240983EU
Cleared2016Studies323Trials27
Cytrellis Biosystems, Inc. · RF & Microneedling
510(k) · clearedClass IIK252752
Cleared2025Studies619Trials135
Cutera, Inc. · Lasers & Light
510(k) · clearedClass IIK182997EU
Cleared2016Studies323Trials27
Candela Corporation · Lasers & Light
510(k) · clearedClass IIK212492EU
Cleared2016Studies1,157Trials128
Solta Medical · Lasers & Light
510(k) · clearedClass IIK242142EU
Cleared2005Studies1,157Trials128
Alma Lasers, Inc. · Lasers & Light
510(k) · clearedClass IIK243044
Cleared2008Studies1,028Trials43
Cynosure, Inc. · Lasers & Light
510(k) · clearedClass IIK142376EU
Cleared2011Studies1,028Trials43
Lutronic Global · Lasers & Light
510(k) · clearedClass IIK192331EU
Cleared2017Studies1,157Trials128
Eclipse Medcorp, LLC · RF & Microneedling
510(k) · clearedClass IIK212558
Cleared2021Studies619Trials135
Candela Corporation · Lasers & Light
510(k) · clearedClass IIK212492EU
Cleared2015Studies1,028Trials43
Wontech Co., Ltd. · Lasers & Light
510(k) · clearedClass IIK181272
Cleared2017Studies323Trials27
Lutronic Corporation · Lasers & Light
510(k) · clearedClass IIK173700
Cleared2018Studies323Trials27
Cynosure, LLC · Lasers & Light
510(k) · clearedClass IIK261570EU
Cleared2012Studies323Trials27
Candela Corporation · Lasers & Light
510(k) · clearedClass IIK220853EU
Cleared2015Studies323Trials27
Refine USA, LLC · RF & Microneedling
510(k) · clearedClass IIK192138
Cleared2020Studies619Trials135
VALEANT PHARMS NORTH · Skin & Topicals
NDA · approvedNDA021108
Approved2000Studies4,253Trials343
BAUSCH · Skin & Topicals
NDA · approvedNDA017340
Approved1973Studies4,253Trials343
Crown Aesthetics · RF & Microneedling
510(k) · clearedClass IIK241400EU
Cleared2018Studies619Trials135
Esthetic Medical, Inc. · RF & Microneedling
510(k) · clearedClass IIK253002
Cleared2020Studies619Trials135
Lumenis Be, Ltd. · Lasers & Light
510(k) · clearedClass IIK250809EU
Cleared2015Studies1,028Trials43
ALMIRALL · Skin & Topicals
NDA · approvedNDA020600
Approved1997Studies4,253Trials343
GALDERMA LABS LP · Skin & Topicals
NDA · approvedNDA021112
Approved2002Studies1,116Trials51
| Product | Manufacturer | Category | Pathway | Class | First decision | Studies | Trials |
|---|---|---|---|---|---|---|---|
| Aklief | GALDERMA LABS LP | Skin & Topicals | NDA — approved | — | Oct 4 2019 | 4,253 | 343 |
| BBL | Sciton, Inc | Lasers & Light | 510(k) — cleared | Class II | Nov 13 2003 | 1,028 | 43 |
| Clear + Brilliant EU | Solta Medical, Inc. | Lasers & Light | 510(k) — cleared | Class II | May 3 2011 | 1,157 | 128 |
| Differin | GALDERMA LABS LP | Skin & Topicals | NDA — approved | — | May 31 1996 | 4,253 | 343 |
| Discovery Pico EU | Quanta System Spa | Lasers & Light | 510(k) — cleared | Class II | Dec 5 2016 | 323 | 27 |
| ellacor | Cytrellis Biosystems, Inc. | RF & Microneedling | 510(k) — cleared | Class II | Oct 30 2025 | 619 | 135 |
| enlighten EU | Cutera, Inc. | Lasers & Light | 510(k) — cleared | Class II | Oct 28 2016 | 323 | 27 |
| Frax EU | Candela Corporation | Lasers & Light | 510(k) — cleared | Class II | Sep 16 2016 | 1,157 | 128 |
| Fraxel EU | Solta Medical | Lasers & Light | 510(k) — cleared | Class II | Jul 5 2005 | 1,157 | 128 |
| Harmony XL | Alma Lasers, Inc. | Lasers & Light | 510(k) — cleared | Class II | May 23 2008 | 1,028 | 43 |
| Icon EU | Cynosure, Inc. | Lasers & Light | 510(k) — cleared | Class II | Jun 22 2011 | 1,028 | 43 |
| LaseMD EU | Lutronic Global | Lasers & Light | 510(k) — cleared | Class II | Jun 23 2017 | 1,157 | 128 |
| MicroPen EVO | Eclipse Medcorp, LLC | RF & Microneedling | 510(k) — cleared | Class II | May 25 2021 | 619 | 135 |
| Nordlys EU | Candela Corporation | Lasers & Light | 510(k) — cleared | Class II | Jul 7 2015 | 1,028 | 43 |
| PicoCare | Wontech Co., Ltd. | Lasers & Light | 510(k) — cleared | Class II | Jun 12 2017 | 323 | 27 |
| PicoPlus | Lutronic Corporation | Lasers & Light | 510(k) — cleared | Class II | Jun 19 2018 | 323 | 27 |
| PicoSure EU | Cynosure, LLC | Lasers & Light | 510(k) — cleared | Class II | Nov 27 2012 | 323 | 27 |
| PicoWay EU | Candela Corporation | Lasers & Light | 510(k) — cleared | Class II | Apr 16 2015 | 323 | 27 |
| Rejuvapen NXT | Refine USA, LLC | RF & Microneedling | 510(k) — cleared | Class II | Apr 9 2020 | 619 | 135 |
| Renova | VALEANT PHARMS NORTH | Skin & Topicals | NDA — approved | — | Aug 31 2000 | 4,253 | 343 |
| Retin-A | BAUSCH | Skin & Topicals | NDA — approved | — | Jan 26 1973 | 4,253 | 343 |
| SkinPen EU | Crown Aesthetics | RF & Microneedling | 510(k) — cleared | Class II | Mar 1 2018 | 619 | 135 |
| SkinStylus | Esthetic Medical, Inc. | RF & Microneedling | 510(k) — cleared | Class II | Apr 10 2020 | 619 | 135 |
| Stellar M22 EU | Lumenis Be, Ltd. | Lasers & Light | 510(k) — cleared | Class II | Jan 21 2015 | 1,028 | 43 |
| Tazorac | ALMIRALL | Skin & Topicals | NDA — approved | — | Jun 13 1997 | 4,253 | 343 |
| Tri-Luma | GALDERMA LABS LP | Skin & Topicals | NDA — approved | — | Jan 18 2002 | 1,116 | 51 |
No product matches these filters.
Missing a device? Report it and it goes into the monthly review.
Curated seed list; study and trial counts are per modality, not per brand. What this measuresThis is a curated seed list of widely used medical-aesthetic products, each crosswalked to a real FDA record where one could be found with confidence. Being listed is not an endorsement, not a ranking and not a claim of market share. Being absent is not a judgement — it means the product is not in this seed list yet. Counts beside each filter are live counts of the products currently matching your other filters. Manufacturer is the applicant or sponsor field of the FDA record, printed exactly as FDA publishes it, so one company can appear under more than one string.
Methodology →
Sorted by most recent FDA decision — a filing date, not a quality signal. What each ordering measuresEvery ordering on this page is a proxy built from public records, never a quality judgement. Orders products by the most recent FDA decision date matched to the brand name, including later submissions and supplements. A recent date means the manufacturer filed again; it does not mean the product is newer, improved, more popular or better. Orders products by the number of PubMed records matching a fixed query for the product's MODALITY, never its brand name. It counts how much has been published about a technique. It is not a quality score, not an efficacy measure, not a count of randomised trials, and not comparable between techniques of different ages. Orders products by the number of ClinicalTrials.gov studies matching a fixed intervention-plus-condition query for the product's MODALITY, never its brand. Registration is not completion, not publication and not a result. Alphabetical by product name. No ranking, quality judgement or ordering of merit is implied by the position of anything in this list. Orders products by the earliest FDA decision date matched to the brand name. For drugs approved under a BLA or NDA the original approval can long predate any cosmetic indication, so an early date is not a cosmetic-use date.
Methodology →
How each product matched (26)
| Product | Matched term | Source string |
|---|---|---|
| Aklief | melasma | ClinicalTrials.gov condition query for Topical retinoid |
| BBL | pigmentation | ClinicalTrials.gov condition query for IPL / broadband light |
| Clear + Brilliant | melasma | ClinicalTrials.gov condition query for Non-ablative fractional laser |
| Differin | melasma | ClinicalTrials.gov condition query for Topical retinoid |
| Discovery Pico | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| ellacor | melasma | ClinicalTrials.gov condition query for Mechanical microneedling |
| enlighten | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| Frax | melasma | ClinicalTrials.gov condition query for Non-ablative fractional laser |
| Fraxel | melasma | ClinicalTrials.gov condition query for Non-ablative fractional laser |
| Harmony XL | pigmentation | ClinicalTrials.gov condition query for IPL / broadband light |
| Icon | pigmentation | ClinicalTrials.gov condition query for IPL / broadband light |
| LaseMD | melasma | ClinicalTrials.gov condition query for Non-ablative fractional laser |
| MicroPen EVO | melasma | ClinicalTrials.gov condition query for Mechanical microneedling |
| Nordlys | pigmentation | ClinicalTrials.gov condition query for IPL / broadband light |
| PicoCare | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| PicoPlus | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| PicoSure | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| PicoWay | melasma | ClinicalTrials.gov condition query for Picosecond laser (pigment & tattoo) |
| Rejuvapen NXT | melasma | ClinicalTrials.gov condition query for Mechanical microneedling |
| Renova | melasma | ClinicalTrials.gov condition query for Topical retinoid |
| Retin-A | melasma | ClinicalTrials.gov condition query for Topical retinoid |
| SkinPen | melasma | ClinicalTrials.gov condition query for Mechanical microneedling |
| SkinStylus | melasma | ClinicalTrials.gov condition query for Mechanical microneedling |
| Stellar M22 | pigmentation | ClinicalTrials.gov condition query for IPL / broadband light |
| Tazorac | melasma | ClinicalTrials.gov condition query for Topical retinoid |
| Tri-Luma | melasma | ClinicalTrials.gov condition query for Topical hydroquinone / triple combination |
Derived by keyword rule from real source strings, not the cleared indication. What this measuresTreatment areas are DERIVED, not copied from an FDA field. A fixed keyword list is run over two real strings: the ClinicalTrials.gov condition query actually executed for this product's modality on the run date, and the device names of the FDA product codes attached to this product's records. The words "skin" and "cosmetic" are ignored because every query contains one of them. An area is not the cleared or approved indication — openFDA's 510(k) response does not carry the indications-for-use text, and this Index does not paraphrase it. Products whose source query names melasma, pigmentation or lentigines.
Methodology →