Merz North America, Inc. · Injectables
PMA · approvedP090016
Approved2011Studies1,298Trials46
Devices linked to volume & folds
18 products · matched by keyword rule, not the cleared indication
18 products
Merz North America, Inc. · Injectables
PMA · approvedP250016
Approved2026Studies1,298Trials46
Merz North America, Inc. · Injectables
PMA · approvedP250020
Approved2026Studies1,298Trials46
Allergan · Injectables
PMA · approvedP050047
Approved2010Studies1,298Trials46
Allergan · Injectables
PMA · approvedP110033
Approved2016Studies1,298Trials46
Allergan · Injectables
PMA · approvedP110033
Approved2017Studies1,298Trials46
Allergan · Injectables
PMA · approvedP110033
Approved2013Studies1,298Trials46
Allergan · Injectables
PMA · approvedP110033
Approved2022Studies1,298Trials46
Maker — · Injectables
No US authorization
Decision—Studies1,298Trials46
Merz North America, Inc. · Injectables
PMA · approvedP050037
Approved2006Studies582Trials7
Q-Med AB · Injectables
PMA · approvedP140029EU
Approved2016Studies1,298Trials46
Q-Med AB · Injectables
PMA · approvedP140029EU
Approved2020Studies1,298Trials46
Q-Med AB · Injectables
PMA · approvedP040024EU
Approved2015Studies1,298Trials46
Q-Med AB · Injectables
PMA · approvedP040024
Approved2014Studies1,298Trials46
Prollenium Medical Technologies, Inc. · Injectables
PMA · approvedP160042
Approved2017Studies1,298Trials46
Teoxane S.A. · Injectables
PMA · approvedP170002
Approved2017Studies1,298Trials46
Q-Med AB · Injectables
PMA · approvedP030050EU
Approved2004Studies586Trials17
Allergan · Injectables
PMA · approvedP110033
Approved2023Studies1,298Trials46
| Product | Manufacturer | Category | Pathway | Class | First decision | Studies | Trials |
|---|---|---|---|---|---|---|---|
| Belotero Balance | Merz North America, Inc. | Injectables | PMA — approved | — | Nov 14 2011 | 1,298 | 46 |
| Belotero Intense (+) Lidocaine | Merz North America, Inc. | Injectables | PMA — approved | — | Jul 9 2026 | 1,298 | 46 |
| Belotero Volume (+) Lidocaine | Merz North America, Inc. | Injectables | PMA — approved | — | May 19 2026 | 1,298 | 46 |
| Juvederm Ultra XC | Allergan | Injectables | PMA — approved | — | Jan 7 2010 | 1,298 | 46 |
| Juvederm Volbella XC | Allergan | Injectables | PMA — approved | — | May 31 2016 | 1,298 | 46 |
| Juvederm Vollure XC | Allergan | Injectables | PMA — approved | — | Mar 17 2017 | 1,298 | 46 |
| Juvederm Voluma XC | Allergan | Injectables | PMA — approved | — | Oct 22 2013 | 1,298 | 46 |
| Juvederm Volux XC | Allergan | Injectables | PMA — approved | — | Jul 29 2022 | 1,298 | 46 |
| Profhilo | — | Injectables | No US authorization found | — | — | 1,298 | 46 |
| Radiesse | Merz North America, Inc. | Injectables | PMA — approved | — | Dec 22 2006 | 582 | 7 |
| Restylane Defyne EU | Q-Med AB | Injectables | PMA — approved | — | Dec 9 2016 | 1,298 | 46 |
| Restylane Kysse EU | Q-Med AB | Injectables | PMA — approved | — | Mar 26 2020 | 1,298 | 46 |
| Restylane Lyft EU | Q-Med AB | Injectables | PMA — approved | — | Aug 31 2015 | 1,298 | 46 |
| Restylane Silk | Q-Med AB | Injectables | PMA — approved | — | Jun 13 2014 | 1,298 | 46 |
| Revanesse Versa | Prollenium Medical Technologies, Inc. | Injectables | PMA — approved | — | Oct 2 2017 | 1,298 | 46 |
| RHA Collection | Teoxane S.A. | Injectables | PMA — approved | — | Oct 19 2017 | 1,298 | 46 |
| Sculptra EU | Q-Med AB | Injectables | PMA — approved | — | Aug 3 2004 | 586 | 17 |
| SKINVIVE by Juvederm | Allergan | Injectables | PMA — approved | — | May 11 2023 | 1,298 | 46 |
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Curated seed list; study and trial counts are per modality, not per brand. What this measuresThis is a curated seed list of widely used medical-aesthetic products, each crosswalked to a real FDA record where one could be found with confidence. Being listed is not an endorsement, not a ranking and not a claim of market share. Being absent is not a judgement — it means the product is not in this seed list yet. Counts beside each filter are live counts of the products currently matching your other filters. Manufacturer is the applicant or sponsor field of the FDA record, printed exactly as FDA publishes it, so one company can appear under more than one string.
Methodology →
Sorted by most recent FDA decision — a filing date, not a quality signal. What each ordering measuresEvery ordering on this page is a proxy built from public records, never a quality judgement. Orders products by the most recent FDA decision date matched to the brand name, including later submissions and supplements. A recent date means the manufacturer filed again; it does not mean the product is newer, improved, more popular or better. Orders products by the number of PubMed records matching a fixed query for the product's MODALITY, never its brand name. It counts how much has been published about a technique. It is not a quality score, not an efficacy measure, not a count of randomised trials, and not comparable between techniques of different ages. Orders products by the number of ClinicalTrials.gov studies matching a fixed intervention-plus-condition query for the product's MODALITY, never its brand. Registration is not completion, not publication and not a result. Alphabetical by product name. No ranking, quality judgement or ordering of merit is implied by the position of anything in this list. Orders products by the earliest FDA decision date matched to the brand name. For drugs approved under a BLA or NDA the original approval can long predate any cosmetic indication, so an early date is not a cosmetic-use date.
Methodology →
How each product matched (18)
| Product | Matched term | Source string |
|---|---|---|
| Belotero Balance | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Belotero Intense (+) Lidocaine | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Belotero Volume (+) Lidocaine | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Juvederm Ultra XC | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Juvederm Volbella XC | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Juvederm Vollure XC | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Juvederm Voluma XC | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Juvederm Volux XC | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Profhilo | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Radiesse | nasolabial fold | ClinicalTrials.gov condition query for Calcium hydroxylapatite filler |
| Restylane Defyne | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Restylane Kysse | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Restylane Lyft | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Restylane Silk | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Revanesse Versa | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| RHA Collection | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
| Sculptra | nasolabial fold | ClinicalTrials.gov condition query for Poly-L-lactic acid collagen stimulator |
| SKINVIVE by Juvederm | nasolabial fold | ClinicalTrials.gov condition query for Hyaluronic acid filler |
Derived by keyword rule from real source strings, not the cleared indication. What this measuresTreatment areas are DERIVED, not copied from an FDA field. A fixed keyword list is run over two real strings: the ClinicalTrials.gov condition query actually executed for this product's modality on the run date, and the device names of the FDA product codes attached to this product's records. The words "skin" and "cosmetic" are ignored because every query contains one of them. An area is not the cleared or approved indication — openFDA's 510(k) response does not carry the indications-for-use text, and this Index does not paraphrase it. Products whose source query names nasolabial folds, lip or hand augmentation, volume deficit or facial lipoatrophy.
Methodology →